Alkylated derivatives of antibiotic BM123γ

Claim 2

A compound selected from the group consisting of those of the formulae: ##STR6## wherein R is a moiety selected from the group consisting of those of the formulae: ##STR7## R 1 is selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, lower alkenyl, phenyl, acetamidophenyl, nitrophenyl, mercaptophenyl, anisyl, tolyl, phenyl lower alkyl, 2-furyl, methyl substituted 2-furyl, 2thienyl, methyl substituted 2-thienyl, 2-pyrryl, methyl substituted 2-pyrryl, 2-pyridyl and 2-quinolyl; and the pharmacologically acceptable acid-addition salts thereof.

Claim 3

A mixture consisting essentially of a compound according to claim 1, formula (I) thereof, wherein R is moiety (V) and a compound according to claim 1, formula (I) thereof, wherein R is moiety (VI).

Claim 4

A mxiture consisting essentially of a compound according to claim 1, formula (II) thereof, wherein R is moiety (V) and a compound according to claim 1, formula (II) thereof, wherein R is moiety (VI).

Claim 5

A mixture consisting essentially of a compound according to claim 1, formula (III) thereof, wherein R is moiety (V) and a compound according to claim 1, formula (III) thereof, wherein R is moiety (VI).

Claim 6

A mixture consisting essentially of a compound according to claim 1, formula (IV) thereof, wherein R is moiety (V) and a compound according to claim 1, formula (IV) thereof, wherein R is moiety (VI).

Claim 7

The mixture in accordance with claim 2 wherein R 1 is hydrogen.

Claim 8

The mixture in accordance with claim 2 wherein R 1 is methyl.

Claim 9

The mixture in accordance with claim 2 wherein R 1 is benzyl.

Claim 10

The mixture in accordance with claim 2 wherein R 1 is 1,1-dimethylpropyl.

Claim 11

The mixture in accordance with claim 2 wherein R 1 is trans-1-methylpropen-1-yl.

Claim 12

The mixture in accordance with claim 3 wherein R 1 is hydrogen.

Claim 13

The mixture in accordance with claim 3 wherein R 1 is methyl.

Claim 14

The mixture in accordance with claim 4 wherein R 1 is hydrogen.

Claim 15

The mixture in accordance with claim 4 wherein R 1 is methyl.

Claim 16

The mixture in accordance with claim 5 wherein R 1 is hydrogen.

Claim 17

The mixture in accordance with claim 5 wherein R 1 is methyl.

Claim 18

A compound selected from the group consisting of those of the formula: ##STR8## wherein R is a moiety selected from the group consisting of those of the formulae: ##STR9## R 2 is selected from the group conisting of lower alkyl, halo substituted lower alkyl and phenyl lower alkyl; R 3 is selected from the group consisting of lower alkyl, halo substituted lower alkyl, lower alkenyl, lower cycloalkyl, phenyl, acetamidophenyl, nitrophenyl, mercaptophenyl, anisyl, tolyl, phenyl lower alkyl, acetamidophenyl lower alkyl, nitrophenyl lower alkyl, mercaptophenyl lower alkyl, anisyl lower alkyl and tolyl lower alkyl; and R 2 and R 3 taken together with the associated methylidyne group is cyclopentyl, mono-lower alkyl substituted cyclopentyl, di-lower alkyl substituted cyclopentyl, tri-lower alkyl substituted cyclopentyl, cyclohexyl, mono-lower alkyl substituted cyclohexyl, di-lower alkyl substituted cyclohexyl or tri-lower alkyl substituted cyclohexyl; and the pharmacologically acceptable acid-addition salts thereof.

Claim 19

A compound selected from the group consisting of those of the formula: ##STR8## wherein R is a moiety selected from the group consisting of those of the formulae: ##STR9## R 2 is selected from the group conisting of lower alkyl, halo substituted lower alkyl and phenyl lower alkyl; R 3 is selected from the group consisting of lower alkyl, halo substituted lower alkyl, lower alkenyl, lower cycloalkyl, phenyl, acetamidophenyl, nitrophenyl, mercaptophenyl, anisyl, tolyl, phenyl lower alkyl, acetamidophenyl lower alkyl, nitrophenyl lower alkyl, mercaptophenyl lower alkyl, anisyl lower alkyl and tolyl lower alkyl; and R 2 and R 3 taken together with the associated methylidyne group is cyclopentyl, mono-lower alkyl substituted cyclopentyl, di-lower alkyl substituted cyclopentyl, tri-lower alkyl substituted cyclopentyl, cyclohexyl, mono-lower alkyl substituted cyclohexyl, di-lower alkyl substituted cyclohexyl or tri-lower alkyl substituted cyclohexyl; and the pharmacologically acceptable acid-addition salts thereof.

Claim 20

A mixture consisting essentially of a compound according to claim 17 wherein R is moiety (A) and a compound according to claim 17 wherein R is moiety (B).

Claim 21

The compound according to claim 17 wherein R is moiety (A), R 2 is methyl, and R 3 is methyl.

Claim 22

The compound according to claim 17 wherein R is moiety (B), R 2 is methyl, and R 3 is methyl.

Claim 23

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is methyl.

Claim 24

The compound according to claim 17 wherein R is moiety (A), R 2 is ethyl, and R 3 is methyl.

Claim 25

The compound according to claim 17 wherein R is moiety (B), R 2 is ethyl, and R 3 is methyl.

Claim 26

The mixture in accordance with claim 18 wherein R 2 is ethyl and R 3 is methyl.

Claim 27

The compound according to claim 17 wherein R is moiety (A), R 2 is ethyl, and R 3 is ethyl.

Claim 28

The compound according to claim 17 wherein R is moiety (B) R 2 is ethyl, and R 3 is ethyl.

Claim 29

The mixture in accordance with claim 18, wherein R 2 is ethyl and R 3 is ethyl.

Claim 30

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is n-propyl.

Claim 31

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is benzyl.

Claim 32

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is 2-methylpropyl.

Claim 33

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is isopropyl.

Claim 34

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is 2,2-dimethylpropyl.

Claim 35

The mixture in accordance with claim 18 wherein R 2 is ethyl and R 3 is butyl.

Claim 36

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is 1-methylpropyl.

Claim 37

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is 2-phenylethyl.

Claim 38

The mixture in accordance with claim 18 wherein R 2 is methyl and R 3 is 3-methylbutyl.