Polyamine compounds and methods for their production
Abstract
Abstract 5-O-(5-AMINO-DEOXY-D-XYLOFURANOSYL)-N1-(4-AMINO2-HYDROXYBUTYRYL9 -4-O- (2,6-DIAMINO-2,6-DIMEOXY-DGLUCOPYRANOSYL) - 2 -DEOXYSTREPTAMINE, ALSO KNOW AS AMINODEOXYBUTIROSIN A. 5 -O- (5-AMINO-5-DEOXY-D-RIBOFURANOSYL) -N1-(4-AMINO-2-HYDROXYBUTYRYL)-4-O-(2,6DIAMINO-2,6-DIDEOXY -D -GLUCOPYRANOSYL) -2-DEOXYSTREPTAMINE, ALSO KNOW AS AMINODEOXYBUTIROSIN B. THESE COMPOUNDS CAN EXIST IN FREE BASE AND IN ACID-ADDITION SALT FORMS. THEY HAVE A WIDE SPECTRUM OF ANTIBACTERIAL ACTIVITY. THEY CAN BE PRODUCED FROM BUTIROSIN A AND BUTIROSIN B, RESPECTIVELY, BY THE SEQUENCE OF REACTIONS WHICH COMPRISES FORMING THE TETRA(TRIFLUOROACETYL) DERIVATIVE CONVERTING THE PRIMARY ALCOHOL GROUP TO AN ARYLSULFONATE ESTER, CONVERTING THE ARYLSULFONATE ESTER GROUP TO THE AZIDO GROUP BY REACTION WITH SODIUM AZIDE, REDUCING THE AZIDO GROUP TO THE AMINO GROUP BY CATALYTIC HYDROGENATION, AND HYDROLYZING THE TRIFLUOROACETYL GROUPS.
Inventors
- 👤 T Culbertson
- 👤 T Haskell
Bibliographic Details
Claims Analysis
Total Claims: 0References Cited (Backward Citations)
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