7-(α-SUBSTITUTED GLYCINAMIDO)-3-SUBSTITUTED METHYL-3-CEPHEM-4-CARBOXYLIC ACIDS AND THEIR DERIVATIVES

Claim 1

Compounds of the formula: ##STR10## wherein R 1 is hydrogen, lower alkyl, phenyl or thienyl; R 2 is phenyl(lower)alkanoyl, phenoxy(lower)alkanoyl or phenylthio(lower)alkanoyl, in which the phenyl moiety may be substituted with one or two halogen atoms, a nitro, carboxy, sulfo, lower alkyl, lower alkoxy, halo(lower)alkyl or phenoxycarbonyl radical; R 3 is a heterocyclic-thio group selected from thiadiazolylthio, oxadiazolylthio, trizolylthio, tetrazolylthio and benzimidazolylthio, in which the heterocyclic moiety may be substituted with lower alkyl, amino(lower)alkyl, in which the amino moiety may have lower alkoxycarbonyl or sulfo(lower)alkyl group, provided that R 1 is hydrogen, lower alkyl or thienyl when R 2 is phenoxy(lower)alkanoyl, in which the phenyl moiety has no substituent and R 3 is lower alkyl substituted; and M is hydrogen or a nontoxic, pharmaceutically acceptable cation; and their lower alkyl, lower alkanoyloxy(lower)alkyl, and phenyl(lower)alkyl esters, wherein the phenyl moiety of the phenyl(lower)alkyl esters may be substituted with lower alkoxy.