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Osmotic therapeutic system for administering medicament

Assignee: Alza Corp
•
Filing: 1976-05-05
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Granted: 1977-07-12
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Expires: 1996-05-05
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Abstract

Abstract An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding in at least a part, a reservoir containing agent. The wall is formed of a material permeable to an external fluid and impermeable to agent. The reservoir is formed of a microporous material permeable to agent and fluid, and having at least one micropore that is a passageway for release of agent. The agent is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid, or the agent has limited solubility in the fluid and is admixed with an osmotically effective compound soluble in fluid that exhibits an osmotic pressure gradient against fluid. In operation, agent is released by fluid permeating through the wall into the reservoir producing a solution of agent or a solution of compound containing agent, which solution in either instance is released through the micropore to the exterior of the device.

Inventors

  • 👤 Felix Theeuwes

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 10:50
CPC Classifications
A; A61; A61F; A61F6/00; A61F6/06; A61F6/14; A61F6/142; A61F6/144; A61F9/00; A61F9/0008; A61F9/0017; A61K; A61K9/00; A61K9/0002; A61K9/0004

Claims Analysis

Total Claims: 21
Claim 1
Independent Claim 213 words
An osmotic therapeutic system for the continuous administration of a medicament to an environment of use, said system comprising: a. a wall formed of a material that maintains its integrity during the administration of medicament, is permeable to the passage of an external fluid present in the environment of use and is substantially impermeable to the passage of medicament, with the wall at least partially surrounding a reservoir; b. a reservoir formed of a material that provides a supporting structure for a multiplicity of microscopic sized interconnected pores; c. a medicament in the reservoir that can be administered from the system to produce a beneficial result; d. a passageway for administering the medicament from the system, said passageway communicating with the reservoir and the interior of the system; and e. wherein in operation with the system in the environment of use, external fluid is continuously imbibed through the wall into the reservoir in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously forming a solution containing medicament which is administered from the system through the passageway to the exterior of the system at a controlled rate over a prolonged period of time to produce the beneficial result.
Claim 2
Dependent Claim 213 words
An osmotic therapeutic system for the continuous administration of a medicament to an environment of use, said system comprising: a. a wall formed of a material that maintains its integrity during the administration of medicament, is permeable to the passage of an external fluid present in the environment of use and is substantially impermeable to the passage of medicament, with the wall at least partially surrounding a reservoir; b. a reservoir formed of a material that provides a supporting structure for a multiplicity of microscopic sized interconnected pores; c. a medicament in the reservoir that can be administered from the system to produce a beneficial result; d. a passageway for administering the medicament from the system, said passageway communicating with the reservoir and the interior of the system; and e. wherein in operation with the system in the environment of use, external fluid is continuously imbibed through the wall into the reservoir in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously forming a solution containing medicament which is administered from the system through the passageway to the exterior of the system at a controlled rate over a prolonged period of time to produce the beneficial result.
Claim 3
Dependent Claim 25 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a central nervous system acting medicament.
Claim 4
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a sedative.
Claim 5
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a transquilizer.
Claim 6
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according th claim 1 wherein the medicament is in anticonvulsant.
Claim 7
Dependent Claim 22 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an antiparkinson medicament.
Claim 8
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an analgesic.
Claim 9
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an antiinflammatory.
Claim 10
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an antispasmodic.
Claim 11
Dependent Claim 22 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a muscle contractant.
Claim 12
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an antimicrobial.
Claim 13
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an antimalarial.
Claim 14
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a sympathomimetic.
Claim 15
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a diuretic.
Claim 16
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is a hypoglycemic.
Claim 17
Dependent Claim 21 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the medicament is an antipyretic.
Claim 18
Dependent Claim 28 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the osmotic system is manufactured in the form of an osmotic device.
Claim 19
Dependent Claim 55 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the number of pores N in the membrane material forming the reservoir is expressed by the following relation: ##EQU6## and wherein ε is the porosity defined as the ratio of void volume to total volume of the membrane material.
Claim 20
Dependent Claim 23 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the material forming the reservoir is isotropic.
Claim 21
Dependent Claim 23 words
The osmotic therapeutic system for the continuous administration of a medicament according to claim 1 wherein the material forming the reservoir is anisotropic.

References Cited (Backward Citations)

US3710795A Cited
US3641237A Cited
US3878977A Cited
US3765414A Cited
US3845770A Cited
US3851648A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-07-11 1981-01-10 1981-07-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-07-11 1985-01-10 1985-07-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-07-11 1989-01-10 1989-07-12 $7700.00 Window Closed / Lapsed

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