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US4034082A
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Method to prevent reproduction in warm-blooded female animals with nonapeptides
Assignee: Abbott Laboratories
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Filing: 1976-03-01
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Granted: 1977-07-05
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Expires: 1996-03-01
Abstract
Abstract With the administration of 1 μg - 10mg/kg of specified nonapeptides, reproduction is prevented in warm-blooded animals of the reproductive age.
Inventors
- 👤 Edwin Samuel Johnson
- 👤 Wilfrid Francis White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:34
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
65 words
A process for preventing reproduction consisting essentially in administering to a female, warm-blooded animal in or before reaching the reproductive age, an effective dose of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenylalanine for at least one day in the period before said female produces one or more mature ova or after ovulation occurred.
Claim 2
Dependent Claim
65 words
A process for preventing reproduction consisting essentially in administering to a female, warm-blooded animal in or before reaching the reproductive age, an effective dose of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenylalanine for at least one day in the period before said female produces one or more mature ova or after ovulation occurred.
Claim 3
Dependent Claim
12 words
The process of claim 1 wherein X in said nonapeptide is D-tryptophane.
Claim 4
Dependent Claim
9 words
The process of claim 1 wherein X is D-phenylalanine.
Claim 5
Dependent Claim
9 words
The process of claim 1 wherein X is D-tyrosine.
Claim 6
Dependent Claim
21 words
The process of claim 1 wherein said nonapeptide is given as a single parenteral dose of between 1 and 500 μg/kg.
Claim 7
Dependent Claim
20 words
The process of claim 1 wherein said dose is administered orally at a dose of between 0.02 and 10 mg/kg.
Claim 8
Dependent Claim
42 words
An oral composition for preventing reproduction in warm-blooded female animals containing between 5 and 100 mg of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenyl-alanine together with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
42 words
An oral composition for preventing reproduction in warm-blooded female animals containing between 5 and 100 mg of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenyl-alanine together with a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-04 | 1981-01-03 | 1981-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-04 | 1985-01-03 | 1985-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-04 | 1989-01-03 | 1989-07-05 | $7700.00 | Window Closed / Lapsed |