US3917825A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation for rectal or vaginal administration containing LH-RH or its analogs
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1973-10-12
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Granted: 1975-11-04
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Expires: 1993-10-12
Abstract
Abstract Novel preparations essentially comprising nona- or deca-peptide having luteinizing hormone-releasing activity dispersed homogeneously in an oleaginous base or in a mixture of the oleaginous base and a non-ionic surfactant effectively exhibit a luteinizing hormone-releasing activity when administered to warmblooded animals by rectal or vaginal route.
Inventors
- 👤 Tai Matsuzawa
- 👤 Shin-Ichiro Hirai
- 👤 Masahiko Fujino
- 👤 Shigeru Kobayashi
- 👤 Iwao Yamazaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 00:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K9/0012; A61K9/0034; C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
38 words
PREPARATION FOR RECTAL OR VAGINL ADMINISTRATION ESSENTIALLY COMPRISING A NONA- OR DECA-PEPTIDE, HAVING LUTEINIZING HORMONE-RELEASING ACTIVITY, OF THE FORMULA: (PYR)GLU-HIS-TRPSER-A1-GLY-A2-ARG-PRO-Y WHEREIN A1 IS TYR OR PHE, A2 IS LEU, NIO, LLE OR MET, AND Y IS -NHC2H5, -NH-C2H4OH,
Claim 2
Dependent Claim
38 words
PREPARATION FOR RECTAL OR VAGINL ADMINISTRATION ESSENTIALLY COMPRISING A NONA- OR DECA-PEPTIDE, HAVING LUTEINIZING HORMONE-RELEASING ACTIVITY, OF THE FORMULA: (PYR)GLU-HIS-TRPSER-A1-GLY-A2-ARG-PRO-Y WHEREIN A1 IS TYR OR PHE, A2 IS LEU, NIO, LLE OR MET, AND Y IS -NHC2H5, -NH-C2H4OH,
Claim 3
Dependent Claim
25 words
The preparation as claimed in claim 1, wherein the oleaginous base is triglyceride of a higher saturated fatty acid of 6 to 30 carbon atoms.
Claim 4
Dependent Claim
23 words
The preparation as claimed in claim 2, wherein the higher saturated fatty acid is palmitic acid, lauric acid, stearic acid or myristic acid.
Claim 5
Dependent Claim
24 words
The preparation as claimed in claim 1, wherein the oleaginous base is triglyceride of saturated vegetable fatty acid containing a minor amount of monoglyceride.
Claim 6
Dependent Claim
25 words
The preparation as claimed in claim 1, wherein an amount of the oleaginous base is about 100 to 200,000 times by weight of the peptide.
Claim 7
Dependent Claim
25 words
The preparation as claimed in claim 1, wherein an amount of the oleaginous base is about 2,000 to 80,000 times by weight of the peptide.
Claim 8
Dependent Claim
14 words
The preparation as claimed in claim 1, wherein the peptide is luteinizing hormone-releasing hormone.
Claim 9
Dependent Claim
15 words
The preparation as claimed in claim 1, wherein the non-ionic surfactant is polyoxyethylene lauryl ether.
Claim 10
Dependent Claim
26 words
The preparation as claimed in claim 1, wherein an amount of the non-ionic surfactant is at least about one hundredth by weight of the oleaginous base.
Claim 11
Dependent Claim
27 words
The preparation as claimed in claim 9, wherein an amount of the non-ionic surfactant is not more than about one tenth by weight of the oleaginous base.
Claim 12
Dependent Claim
20 words
The preparation as claimed in claim 1, wherein the non-ionic surfactant has an HLB value of about 7 to 18.
Claim 13
Dependent Claim
20 words
The preparation as claimed in claim 1; wherein the non-ionic surfactant has an HLB value of about 9 to 14.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |