US4034082A
Expired / Lapsed
US
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Method to prevent reproduction in warm-blooded female animals with nonapeptides
Assignee: Abbott Laboratories
•
Filing: 1976-03-01
•
Granted: 1977-07-05
•
Expires: 1996-03-01
Abstract
Abstract With the administration of 1 μg - 10mg/kg of specified nonapeptides, reproduction is prevented in warm-blooded animals of the reproductive age.
Inventors
- 👤 Edwin Samuel Johnson
- 👤 Wilfrid Francis White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:27
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
65 words
A process for preventing reproduction consisting essentially in administering to a female, warm-blooded animal in or before reaching the reproductive age, an effective dose of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenylalanine for at least one day in the period before said female produces one or more mature ova or after ovulation occurred.
Claim 2
Dependent Claim
65 words
A process for preventing reproduction consisting essentially in administering to a female, warm-blooded animal in or before reaching the reproductive age, an effective dose of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenylalanine for at least one day in the period before said female produces one or more mature ova or after ovulation occurred.
Claim 3
Dependent Claim
12 words
The process of claim 1 wherein X in said nonapeptide is D-tryptophane.
Claim 4
Dependent Claim
9 words
The process of claim 1 wherein X is D-phenylalanine.
Claim 5
Dependent Claim
9 words
The process of claim 1 wherein X is D-tyrosine.
Claim 6
Dependent Claim
21 words
The process of claim 1 wherein said nonapeptide is given as a single parenteral dose of between 1 and 500 μg/kg.
Claim 7
Dependent Claim
20 words
The process of claim 1 wherein said dose is administered orally at a dose of between 0.02 and 10 mg/kg.
Claim 8
Dependent Claim
42 words
An oral composition for preventing reproduction in warm-blooded female animals containing between 5 and 100 mg of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenyl-alanine together with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
42 words
An oral composition for preventing reproduction in warm-blooded female animals containing between 5 and 100 mg of the nonapeptide L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C 2 H 5 wherein X denotes the divalent, optically active D-form of tryptophane, tyrosine or phenyl-alanine together with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
US3784535A
Cited
US3853837A
Cited
US3888838A
Cited
US3880825A
Cited
US3917825A
Cited
US3890437A
Cited
US3914412A
Cited
US3886137A
Cited
US3892723A
Cited
US3886135A
Cited
US3915947A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-04 | 1981-01-03 | 1981-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-04 | 1985-01-03 | 1985-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-04 | 1989-01-03 | 1989-07-05 | $7700.00 | Window Closed / Lapsed |