Penicillins and processes for their preparation and use

Claim 1

A compound selected from the group consisting of a penicillin of the formula: ##STR39## and the pharmaceutically acceptable salts thereof, wherein the carbon atom designated * constitutes a center of chirality; A is hydrogen or methoxy; B is phenyl, hydroxyphenyl, halophenyl, methoxyphenyl, cyanophenyl, methylsulfonylphenyl, thienyl, cyclohexenyl or cyclohexa-1,4-dien-1-yl; each of R, R 1 and R 2 is independently selected from the group consisting of hydrogen, halo, lower alkyl, halo(lower)alkyl, carboxy, formyl, carbo(lower alkoxy), lower alkanoyl, cyano, carbamyl, lower alkylcarbamyl, di(lower alkyl)carbamyl, lower alkylamino, di(lower alkyl)amino, pyrrolidino, piperidino, formamido, lower alkanamido, N-(lower alkyl)formamido, N-(lower alkyl)lower alkanamido, lower alkylidenimino, lower alkylsulfonamido, n-(lower alkyl)lower alkylsulfonamido, sulfamino, N-(lower alkyl)sulfamino, amidino, di(lower alkyl)aminomethylidenimino, pyrrolidinomethylidenimino, guanido, nitro, azido, carbo(lower alkoxy)amino, N-(lower alkyl)carbo(lower alkoxy)-amino, hydroxy, lower alkoxy, formyloxy, lower alkanoyloxy, lower alkoxycarbonyloxy, carbamyloxy, N-(lower alkyl)carbamyloxy, N,N-di(lower alkyl)-carbamyloxy, pyrrolidinocarboxyloxy, sulfamyl, N-(lower alkyl)sulfamyloxy, N,N-di(lower alkyl)-sulfamyloxy, mercapto, lower alkylthio, trifluoromethylthio, lower alkylsulfonyl, sulfo, lower alkylsulfinyl, trifluoromethylsulfonyl, sulfamyl, N-(lower alkyl)sulfamyl, N,N-di(lower alkyl)sulfamyl, pyrrolidinosulfonyl, and sulfothio; and E is oxygen or sulfur.