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US4029650A
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Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them
Assignee: Synthelabo SA
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Filing: 1975-11-20
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Granted: 1977-06-14
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Expires: 1995-11-20
Abstract
Abstract Compounds having the formula <IMAGE> +TR <IMAGE> in which R1 is alkyl having no more than 4 carbon atoms and R2 is dimethoxyphenylethyl or <IMAGE> is piperidino, heptamethyleneimino or 1,2,3,4-tetrahydroisoquinolino. The compounds are prepared by condensing N-(3,4,5-trimethoxy cinnamoyl)N'-(carboxymethyl) piperazine with <IMAGE>
Inventors
- 👤 Guy M. Raynaud
- 👤 Bernard M. Pourrias
- 👤 Claude P. Fauran
- 👤 Michel J. Turin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 08:23
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/185; A; A61; A61P; A61P9/00; A61P9/08; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
39 words
A compound having the formula ##STR14## in which R 1 is alkyl having one to 4 carbon atoms and R 2 is dimethoxyphenylethyl, or ##STR15## is piperidino, heptamethylenimino or 1,2,3,4-tetrahydro isoquinolino, and the pharmacologically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
39 words
A compound having the formula ##STR14## in which R 1 is alkyl having one to 4 carbon atoms and R 2 is dimethoxyphenylethyl, or ##STR15## is piperidino, heptamethylenimino or 1,2,3,4-tetrahydro isoquinolino, and the pharmacologically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
24 words
A compound as claimed in claim 1, in which R 1 is alkyl having one to 4 carbon atoms and R 2 is dimethoxyphenylethyl.
Claim 4
Dependent Claim
18 words
A compound as claimed in claim 2, in which R 1 is methyl and R 2 is 3,4-dimethoxyphenylethyl.
Claim 5
Dependent Claim
12 words
A compound as claimed in claim 1 in which ##STR16## is piperidino.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1 in which ##STR17## is heptamethylenimino.
Claim 7
Dependent Claim
13 words
A compound as claimed in claim 1 in which ##STR18## is 1,2,3,4-tetrahydro isoquinolino.
Claim 8
Dependent Claim
60 words
A process for preparing a compound having the formula ##STR19## in which R 1 is alkyl having one to 4 carbon atoms and R 2 is dimethoxyphenylethyl, or ##STR20## is piperidino, heptamethylenimino or 1,2,3,4-tetrahydro isoquinolino, which comprises reacting a starting compound having the formula ##STR21## which is a secondary amine having the formula ##STR22## in the presence of butyl chloroformate.
Claim 9
Dependent Claim
60 words
A process for preparing a compound having the formula ##STR19## in which R 1 is alkyl having one to 4 carbon atoms and R 2 is dimethoxyphenylethyl, or ##STR20## is piperidino, heptamethylenimino or 1,2,3,4-tetrahydro isoquinolino, which comprises reacting a starting compound having the formula ##STR21## which is a secondary amine having the formula ##STR22## in the presence of butyl chloroformate.
Claim 10
Dependent Claim
36 words
A process as claimed in claim 7 in which said starting compound is dissolved in anhydrous tetrahydrofuran, then triethylamine and butyl chloroformate are added to the solution and then said amine is added to the solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |