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US4026895A
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1,3-Benzodioxol derivatives
Assignee: Eisai Co Ltd
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Filing: 1975-08-29
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Granted: 1977-05-31
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Expires: 1995-08-29
Abstract
Abstract 1,3-Benzodioxol derivatives, the new compounds, represented by the formula: ##STR1## and the pharmacologically acceptable acid-addition salts thereof are provided, wherein R 1 and R 2 are lower alkyls or the both together may form a divalent alkylene, R 3 is a lower alkyl, phenyl, halogen-substituted phenyl or benzhydryl group, n is an integer of 2 or 3, and X stands for carbonyl (CO) or methylene (CH 2 ) bridge. The compounds in which X stands for the methylene exhibit durable anti-histamic activity with low toxicity, and are useful for therapeutic purposes, while the compounds in which X stands for the carbonyl bridge are easily convertible by reduction into the former compounds.
Inventors
- 👤 Satoru Tanaka
- 👤 Hideaki Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:33
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
68 words
A member of the group consisting of a compound of the formula: ##STR62## wherein R 1 and R 2 are respectively lower alkyl of 1 to 2 carbon atoms or both R 1 and R 2 together form divalent alkylene of 5 carbon atoms as a part of a cyclic structural moiety; and R 3 is methyl, phenyl, chlorophenyl or benzhydryl; and a pharmacologically acceptable acid-addition salt thereof.
Claim 2
Dependent Claim
68 words
A member of the group consisting of a compound of the formula: ##STR62## wherein R 1 and R 2 are respectively lower alkyl of 1 to 2 carbon atoms or both R 1 and R 2 together form divalent alkylene of 5 carbon atoms as a part of a cyclic structural moiety; and R 3 is methyl, phenyl, chlorophenyl or benzhydryl; and a pharmacologically acceptable acid-addition salt thereof.
Claim 3
Dependent Claim
25 words
A compound according to claim 1 wherein R 1 is --Ch 3 , R 2 is --C 2 H 5 and R 3 is benzhydryl.
Claim 4
Dependent Claim
27 words
A compound according to claim 1 wherein R 1 is --CH 3 , R 2 is --C 2 H 5 and R 3 is --CH 3 .
Claim 5
Dependent Claim
28 words
A compound according to claim 1 wherein R 1 and R 2 together represent the group --(CH 2 ) 5 -- and R 3 represents --CH 3 .
Claim 6
Dependent Claim
24 words
A compound according to claim 1 wherein R 1 and R 2 together represent --(CH 2 ) 5 -- and R 3 represents benzhydryl.
Claim 7
Dependent Claim
19 words
A compound according to claim 1 wherein R 1 , R 2 and R 3 represent --CH 3 .
References Cited (Backward Citations)
US3119826A
Cited
US3981864A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-30 | 1980-11-29 | 1981-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-30 | 1984-11-29 | 1985-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-30 | 1988-11-29 | 1989-05-31 | $7700.00 | Window Closed / Lapsed |