US4025640A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxothienobenzoxepin-acetic acids, precursors and derivatives thereof
Assignee: CNA Holdings LLC
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Filing: 1975-08-26
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Granted: 1977-05-24
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Expires: 1995-08-26
Abstract
Abstract Oxothienobenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and process for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.
Inventors
- 👤 Arthur Raymond McFadden
- 👤 Daniel Eugene Aultz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:18
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; C07D213/80; C07D207/00; C07D207/02; C07D207/30; C07D207/34; C07D307/00; C07D307/02; C07D307/34; C07D307/56; C07D307/68; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38; C07D491/00; C07D491/02; C07D491/04; C07D493/00; C07D493/02; C07D493/04; C07D495/00; C07D495/02; C07D495/04
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
73 words
A compound of the formula ##STR6## wherein X together with the carbon atoms to which it is attached is a thieno ring structure; R is hydrogen or straight or branched chain alkyl of from 1 to 5 carbon atoms; R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; R 2 is hydrogen or methyl; n is the integer 1, 2 or 3; and salts thereof prepared from pharmaceutically acceptable bases.
Claim 2
Dependent Claim
73 words
A compound of the formula ##STR6## wherein X together with the carbon atoms to which it is attached is a thieno ring structure; R is hydrogen or straight or branched chain alkyl of from 1 to 5 carbon atoms; R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; R 2 is hydrogen or methyl; n is the integer 1, 2 or 3; and salts thereof prepared from pharmaceutically acceptable bases.
Claim 3
Dependent Claim
54 words
A compound of the formula ##STR7## wherein X together with the carbon atoms to which it is attached is a thieno ring structure; R is hydrogen or straight or branched chain alkyl of from 1 to 5 carbon atoms; and R 2 is hydrogen or methyl; and salts thereof prepared from pharmaceutically acceptable bases.
Claim 4
Dependent Claim
54 words
A compound of the formula ##STR7## wherein X together with the carbon atoms to which it is attached is a thieno ring structure; R is hydrogen or straight or branched chain alkyl of from 1 to 5 carbon atoms; and R 2 is hydrogen or methyl; and salts thereof prepared from pharmaceutically acceptable bases.
Claim 5
Dependent Claim
30 words
A compound defined in claim 2 of the formula ##STR8## in which R and R 2 are as defined in claim 2; and salts thereof prepared from pharmaceutically acceptable bases.
Claim 6
Dependent Claim
10 words
The compound defined in claim 2 which is 4,10-dihydro-10-oxothieno[2,3-c][1]benzoxepin-8-acetic acid.
Claim 7
Dependent Claim
10 words
The compound defined in claim 2 which is 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetic acid.
Claim 8
Dependent Claim
10 words
The compound defined in claim 2 which is methyl 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetate.
Claim 9
Dependent Claim
10 words
The compound defined in claim 2 which is isopropyl 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetate.
Claim 10
Dependent Claim
34 words
A pharmaceutical composition which comprises between about 0.5 and about 70 percent by weight of a compound defined in claim 1 as an essential active ingredient, the balance being a pharmaceutically acceptable carrier therefor.
Claim 11
Dependent Claim
33 words
A pharmaceutical composition which comprises between about 0.5 and about 70% by weight of the compound defined in claim 7 as an essential active ingredient, the balance being a pharmaceutically acceptable carrier therefor.
Claim 12
Dependent Claim
21 words
A method of treating inflammation which comprises administering to a patient an effective amount of a compound defined in claim 1.
Claim 13
Dependent Claim
21 words
A method of alleviating pain which comprises administering to a patient an effective amount of a compound defined in claim 1.
Claim 14
Dependent Claim
22 words
A method of treating systemic inflammation which comprises administering to a patient an effective amount of a compound defined in claim 1.
Claim 15
Dependent Claim
22 words
A method of treating systemic inflammation which comprises administering to a patient an effective amount of the compound defined in claim 7.
Claim 16
Dependent Claim
27 words
A method of treating dermal inflammation which comprises topically administering to the inflamed area of a patient an effective amount of a compound defined in claim 1.
Claim 17
Dependent Claim
27 words
A method of treating dermal inflammation which comprises topically administering to the inflamed area of a patient an effective amount of the compound defined in claim 7.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-23 | 1980-11-22 | 1981-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-23 | 1984-11-22 | 1985-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-23 | 1988-11-22 | 1989-05-24 | $7700.00 | Window Closed / Lapsed |