US3865843A
Expired / Lapsed
US
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4-Oxo-4H-benzo{8 4.5{9 cyclohepta{8 1,2-b{9 thiophene derivatives
Assignee: Sandoz AG
•
Filing: 1973-04-02
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Granted: 1975-02-11
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Expires: 1993-04-02
Abstract
Abstract The invention concerns novel 4-oxo-4H-benzo(4,5)cycloheptal(1,2b)thiophene derivatives of the formula WHEREIN R1 is hydrogen or lower alkyl, R2 IS HYDROGEN, FLUORINE, CHLORINE, BROMINE, LOWER ALKYL OR LOWER ALKOXY, R3 is hydrogen or lower alkyl, and A is ethylene or vinylene, useful as ANTIPHLOGISTIC AGENTS.
Inventors
- 👤 Jean-Michel Bastian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:53
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/50; C07D333/78; C07D333/80
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
9 words
The compound of claim 1, which is 9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 4
Dependent Claim
10 words
The compound of claim 1, which is 4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 5
Dependent Claim
9 words
The compound of claim 1, which is 6-chloro-9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 6
Dependent Claim
11 words
The compound of claim 1, which is 9,10-dihydro- Alpha -methyl-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 7
Dependent Claim
9 words
The compound of claim 1, which is 7-chloro-9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 8
Dependent Claim
13 words
The compound of claim 1, which is 9,10-dihydro- Alpha -methyl-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 9
Dependent Claim
11 words
The compound of claim 1, which is 9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 10
Dependent Claim
12 words
The compound of claim 1, which is 4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 11
Dependent Claim
11 words
The compound of claim 1, which is 6-chloro-9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohepta(1,2-)thiophene-2-acetic acid ethyl ester.
Claim 12
Dependent Claim
12 words
The compound of claim 1, which is 6-chloro-9,10-dihydro-Alpha -methyl-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 13
Dependent Claim
11 words
The compound of claim 1, which is 7-chloro-9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohetpa(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 14
Dependent Claim
12 words
The compound of claim 1, which is 4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid methyl ester.
Claim 15
Dependent Claim
11 words
The compound of claim 1, which is 6-chloro-9,10-dihydro-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid methyl ester.
Claim 16
Dependent Claim
55 words
A compound of claim 1, wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, R3 is hydrogen or alkyl of 1 to 5 carbon atoms and A is ethylene or vinylene.
Claim 17
Dependent Claim
17 words
A compound of claim 15, wherein R2 is hydrogen, fluorine, chlorine or bromine and R3 is hydrogen.
Claim 18
Dependent Claim
15 words
A compound of claim 15, wherein R3 is alkyl of 1 to 5 carbon atoms.
Claim 19
Dependent Claim
21 words
A compound of claim 1 wherein R2 is hydrogen, fluorine, chlorine, bromine or lower alkoxy in the 6 or 7 position.
Claim 20
Dependent Claim
16 words
A compound of claim 18 wherein R1 is lower alkyl having 1 to 4 carbon atoms.
Claim 21
Dependent Claim
9 words
A compound of claim 18 wherein R2 is hydrogen.
Claim 22
Dependent Claim
10 words
The compound of claim 1 which is 6-chloro-9,10-dihydro-Alpha -methyl-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 23
Dependent Claim
10 words
The compound of claim 1 which is 6-fluoro-4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 24
Dependent Claim
10 words
The compound of claim 1 which is 5-methyl-4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid.
Claim 25
Dependent Claim
12 words
The compound of claim 1, which is 6-fluoro-4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 26
Dependent Claim
12 words
The compound of claim 1 which is 5-methyl-4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid ethyl ester.
Claim 27
Dependent Claim
12 words
The compound of claim 1 which is 9,10-dihydro-6-methoxy-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2 -acetic acid methyl ester.
Claim 28
Dependent Claim
12 words
The compound of claim 1 which is 6-fluoro-4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid methyl ester.
Claim 29
Dependent Claim
12 words
The compound of claim 1 which is 5-methyl-4-oxo-4H-benzo(4, 5)cyclohepta(1,2-b)thiophene-2-acetic acid methyl ester.
Claim 30
Dependent Claim
10 words
The compound of claim 1 which is 9,10-dihydro-6-methoxy-4-oxo-4H-benzo(4,5)cyclohepta(1,2-b)thiophene-2 -acetic acid.
References Cited (Backward Citations)
US3464983A
Cited
US3780061A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-10 | 1978-08-12 | 1979-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-10 | 1982-08-12 | 1983-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-10 | 1986-08-12 | 1987-02-11 | $7700.00 | Window Closed / Lapsed |