Bi-4-[1-(quinazolinyl-4)piperidyls] and bis{4-[1-(quinazolinyl-4)piperidyl]alkanes}

Claim 1

A compound selected from the group consisting of: a. compounds of the formula I: ##STR15## b. compounds of the formula Iq: ##STR16## and c. compounds of the formula Ir: ##STR17## wherein R and R 1 are independently hydrogen or alkyl of 1 to 4 carbon atoms, n is 0 to 4, m is 0 to 1, p is 0 or 1, each Y is independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 3 carbon atoms, alkylthio of 1 to 3 carbon atoms, hydroxy, formamido, trifluoromethyl, nitro, cyano, amino, hydroxylamino, N-monoalkylamino of 1 to 4 carbon atoms, N,N-dialkylamino in which each alkyl is of 1 to 3 carbon atoms, alkanoylamino of 2 to 4 carbon atoms, N-alkyl (of 1 to 3 carbon atoms), N-alkanoyl (of 2 to 4 carbon atoms) amino or N-alkyl (of 1 to 3 carbon atoms), N-formylamino or two adjacent Y together form 6,7-methylenedioxy or 6,7-ethylenedioxy (with the other Y on each A and B ring so substituted being hydrogen), subject to the proviso that: (1) adjacent Ys are not both tert-butyl; (2) no more than 2 Ys in each A and B ring are substituents selected from the group consisting of trifluoromethyl, nitro, cyano, hydroxy, formamido, alkylthio, amino, N-alkylamino, N,N-dialkylamino, hydroxylamino, alkanoylamino, N-alkyl, N-alkanoylamino and N-alkyl, N-formylamino; (3) when any Y in an A or B ring is amino, cyano, hydroxylamino, N-alkylamino, N,N-dialkylamino, alkanoylamino, formamido, N-alkyl, N-alkanoylamino or N-alkyl, N-formylamino, then any dissimilar Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl and alkoxy; and (4) when any Y is hydroxy, then no other Y is a dissimilar substituent selected from the group consisting of alkoxy and alkylthio, each Y' is independently hydrogen, chloro, bromo or alkyl of 1 to 4 carbon atoms, each Y" is independently hydrogen, chloro, bromo or straight chain alkyl of 1 to 4 carbon atoms, each Y'" is independently hydrogen or straight chain alkyl of 1 to 4 carbon atoms, each Y q is independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 3 carbon atoms, trifluoromethyl or nitro or two adjacent Yq together form 6,7-methylenedioxy or 6,7-ethylenedioxy with the other Y on each A and B ring so substituted being hydrogen, subject to the provisos that: (1) adjacent Yq's are not both tert-butyl; and (2) no more than two Yq's in each A and B ring are substituents selected from the group consisting of trifluoromethyl and nitro, Rq is alkyl of 1 to 4 carbon atoms which is unbranched on the α-carbon atom, and X is a pharmaceutically acceptable inorganic anion, or a pharmaceutically acceptable acid addition salt of a compound of the formula I and Ir.