US3931179A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N,N-Bis(4-Quinazolinyl)alkanediamines
Assignee: Sandoz Inc
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Filing: 1974-03-06
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Granted: 1976-01-06
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Expires: 1994-03-06
Abstract
Abstract Disclosed are N,N'-Bis(4-Quinazolinyl)alkanediamines, e.g., N,N'-Bis(7-chloro-4-quinazolinyl)-1,9-nonanediamine, having pharmacological activity in animals and useful for example, as anti-obesity agents. Said compounds may be prepared by reacting a 4-haloquinazoline with an alkanediamine.
Inventors
- 👤 William R. J. Simpson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:15
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; C; C07; C07D; C07D239/00; C07D239/70; C07D239/72; C07D239/86; C07D239/94
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
165 words
A compound of the formula: ##SPC5## wherein R and R 1 are independently hydrogen or alkyl of 1 to 4 carbon atoms, n is 0 to 12, each Y is independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl, nitro, amino or N,N-dialkylamino in which each alkyl is of 1 to 3 carbon atoms or two adjacent Y together form 6,7-methylenedioxy or 6,7-ethylenedioxy with the other Y on any such alkylenedioxy substituted ring being hydrogen, provided that adjacent Ys do not both have a tert-butyl moiety, further provided that no more than 2 Ys in each A and B ring are nitro, trifluoromethyl, amino or dialkylamino, and also provided that when any Y is amino or dialkylamino, then any dissimilar Y is hydrogen, fluoro, chloro, bromo, alkyl or alkoxy, and each Y' is independently hydrogen, fluoro, chloro, bromo or alkyl of 1 to 4 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
165 words
A compound of the formula: ##SPC5## wherein R and R 1 are independently hydrogen or alkyl of 1 to 4 carbon atoms, n is 0 to 12, each Y is independently hydrogen, fluoro, chloro, bromo, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl, nitro, amino or N,N-dialkylamino in which each alkyl is of 1 to 3 carbon atoms or two adjacent Y together form 6,7-methylenedioxy or 6,7-ethylenedioxy with the other Y on any such alkylenedioxy substituted ring being hydrogen, provided that adjacent Ys do not both have a tert-butyl moiety, further provided that no more than 2 Ys in each A and B ring are nitro, trifluoromethyl, amino or dialkylamino, and also provided that when any Y is amino or dialkylamino, then any dissimilar Y is hydrogen, fluoro, chloro, bromo, alkyl or alkoxy, and each Y' is independently hydrogen, fluoro, chloro, bromo or alkyl of 1 to 4 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
12 words
A compound of claim 1 in which n is 6 to 10.
Claim 4
Dependent Claim
15 words
A compound of claim 2 in which each of R and R 1 is hydrogen.
Claim 5
Dependent Claim
8 words
The compound of claim 3 which is N,N'-Bis(7-chloro-4-quinazolinyl)-1,9-nonanediamine.
Claim 6
Dependent Claim
8 words
The compound of claim 3 which is N,N'-Bis(7-trifluoromethyl-4-quinazolinyl)-1,9-nonanediamine.
Claim 7
Dependent Claim
8 words
The compound of claim 3 which is N,N'-Bis(6,8-dichloro-4-quinazolinyl)-1,9-nonanediamine.
Claim 8
Dependent Claim
10 words
A compound of claim 1 in which n is 7.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-05 | 1979-07-07 | 1980-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-05 | 1983-07-07 | 1984-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-05 | 1987-07-07 | 1988-01-06 | $7700.00 | Window Closed / Lapsed |