US3971783A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-Aminoquinazoline derivatives as cardiac stimulants
Assignee: Pfizer Inc
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Filing: 1974-04-26
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Granted: 1976-07-27
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Expires: 1994-04-26
Abstract
Abstract Certain novel 7-alkoxy-4-(N-[ omega -(heteroaryl)alkyl]amino)quinazoline compounds, optionally bearing an alkyl or substituted alkyl group at the 2-position, an alkyl, benzyl, phenyl or alkoxyphenyl group on the 4-amino nitrogen atom, an alkyl or alkoxy group at the 5-position, and an alkyl alkoxy, hydroxy or amino group at the 6-position; and the acid-addition salts thereof. Compounds are cardiac stimulants.
Inventors
- 👤 Ian Thompson Barnish
- 👤 David Alexander Cox
- 👤 Anthony Garth Evans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 15:42
CPC Classifications
C; C07; C07D; C07D417/00; C07D417/02; C07D417/12; C07D401/00; C07D401/02; C07D401/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
190 words
A compound of the formula ##SPC4## or a pharmaceutically acceptable acid-addition salt thereof; wherein R 2 is selected from the group consisting of hydrogen, alkyl having from one to six carbon atoms, hydroxyalkyl having from one to six carbon atoms and alkoxyalkyl having from two to six carbon atoms; R 3 is selected from the group consisting of hydrogen, benzyl, alkyl having from one to six carbon atoms, phenyl and alkoxyphenyl having from one to six carbon atoms in said alkoxy group; R 4 is selected from the group consisting of pyridyl, quinolyl, thiazolyl, imidazolyl, pyrazinyl, indolyl, hydroxypyridyl, alkylpyridyl having from one to six carbon atoms in said alkyl group and alkylthiazolyl having from one to six carbon atoms in said alkyl group; R 5 is hydrogen; R 6 is selected from the group consisting of hydrogen, alkyl having from one to six carbon atoms, alkoxy having from one to six carbon atoms, hydroxy and amino; R 7 is alkoxy having from one to six carbon atoms; and n is 1, 2, 3 or 4; providing that R 4 is linked to (CH 2 ) n through a ring-carbon atom.
Claim 2
Dependent Claim
190 words
A compound of the formula ##SPC4## or a pharmaceutically acceptable acid-addition salt thereof; wherein R 2 is selected from the group consisting of hydrogen, alkyl having from one to six carbon atoms, hydroxyalkyl having from one to six carbon atoms and alkoxyalkyl having from two to six carbon atoms; R 3 is selected from the group consisting of hydrogen, benzyl, alkyl having from one to six carbon atoms, phenyl and alkoxyphenyl having from one to six carbon atoms in said alkoxy group; R 4 is selected from the group consisting of pyridyl, quinolyl, thiazolyl, imidazolyl, pyrazinyl, indolyl, hydroxypyridyl, alkylpyridyl having from one to six carbon atoms in said alkyl group and alkylthiazolyl having from one to six carbon atoms in said alkyl group; R 5 is hydrogen; R 6 is selected from the group consisting of hydrogen, alkyl having from one to six carbon atoms, alkoxy having from one to six carbon atoms, hydroxy and amino; R 7 is alkoxy having from one to six carbon atoms; and n is 1, 2, 3 or 4; providing that R 4 is linked to (CH 2 ) n through a ring-carbon atom.
Claim 3
Dependent Claim
11 words
A compound according to claim 1, wherein R 4 is pyridyl.
Claim 4
Dependent Claim
12 words
A compound according to claim 2, wherein R 6 is said alkoxy.
Claim 5
Dependent Claim
15 words
A compound according to claim 3, wherein R 6 and R 7 are each methoxy.
Claim 6
Dependent Claim
19 words
A compound according to claim 4, wherein R 2 is selected from the group consisting of hydrogen and methyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 5, wherein n is 2.
Claim 8
Dependent Claim
19 words
A compound according to claim 6, wherein R 3 is selected from the group consisting of hydrogen and methyl.
Claim 9
Dependent Claim
11 words
A compound according to claim 7, wherein R 4 is 2-pyridyl.
Claim 10
Dependent Claim
16 words
The compound according to claim 8, wherein R 2 is hydrogen and R 3 is methyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |