Abstract Chromone derivatives of the formula: ##STR1## wherein R 1 is alkoxy, an N,S-containing heterocyclic group or aryloxy in which heterocyclic group may be substituted with halogen or acyl, and aryl may be substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy; R 2 is alkylene; R 3 is hydroxy, alkoxy or a group of the formula ##STR2## in which R 4 is hydrogen, R 5 is hydroxy or amino or R 4 and R 5 means taken together with the adjacent nitrogen atom, piperazinyl substituted with alkyl or hydroxyalkyl; provided that when R 3 is hydroxy or alkoxy, R 1 is an N,S-containing heterocyclic group or aryloxy in which heterocyclic group is substituted with halogen or acyl, and aryl is substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy, and nontoxic, pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents.
A compound of the formula: ##STR31## wherein R 1 is aryloxy substituted with lower alkylenedioxy, said aryloxy being phenoxy, napthyloxy, tolyloxy, xylyloxy, mesityloxy or cumenyloxy; R 2 is lower alkylene; R 3 is hydroxy or lower alkoxy or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
44 words
A compound of the formula: ##STR31## wherein R 1 is aryloxy substituted with lower alkylenedioxy, said aryloxy being phenoxy, napthyloxy, tolyloxy, xylyloxy, mesityloxy or cumenyloxy; R 2 is lower alkylene; R 3 is hydroxy or lower alkoxy or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
11 words
A compound of claim 1 in which R 1 is 3,4-methylenedioxy-phenoxy.
Claim 4
Dependent Claim
12 words
A compound of claim 1 in which said compound is sodium 5-[2-(3,4-methylenedioxyphenoxy)ethoxy]chromone-2-carboxylate.
Claim 5
Dependent Claim
12 words
A compound of claim 1 in which said compound is ethyl 5-[2-(3,4-methylenedioxyphenoxy)ethoxy]chromone-2-carboxylate.