Derivatives of chromone-2-carboxylic acid

Abstract

Abstract CHROMONE DERIVATIVES OF THE FORMULA 2-(HOOC-),3-R1,4-(O=),5-P,6-Q,7-R,8-T-4H-CHROMENE IN WHICH AT LEAST ONE OF Q, R OR T REPRESENTS -OY WHEREIN Y IS SELECTED FROM THE GROUP CONSISTING OF HYDROXY-ALKYL, ALKOXY-ALKYL, CARBOXYL-ALKYL, DIHYDROXYALKYL, ALKOXY-ALKOXY-ALKYL, ALKOXY-HYDROXY-ALKYL, PHENOXYALKYL, FURFURYL, TETRAHYDROFURFURAL, DIOXOLANYL, ALKYL SUBSITUTED DIOXOLANYL, GLUCOSYL AND RIBOSYL IN WHICH GROUPS THE ALKYL AND ALKOXY PORTIONS ARE LOWER ALKYL OR LOWR ALKOXY, P AND THOSE OF Q, R AND T WHICH DO NOT FORM A -OY GROUP ARE SELECTED FROM HYDROGEN, HALOGEN, ALKYL CONTAINING FROM 1 TO 10 CARBON ATOMS, ALKYL CONTAINING FROM 1 TO 10 CARBON ATOMS AND SUBSTITUTED BY HALOGE, HYDROXY OR LOWER ALKOXY; HYDROXY, ALKOXY CONTAINING FROM 1 TO 10 CARBON ATOMS, CARBOXY, NITRO, LOWER ALKYLAMINO, DI-LOWER ALKYL AMINO OR ANILINO, OR AN ADJACENT PAIR OF P AND THOSE OF Q, R, AND T WHICH DO NOT REPRESENT A -OY GROUP, TOGETHER WITH THE ADJACENT CARBON ATOMS ON THE BENZENE RING, FORM A PYRIDINE OR BENZENE RING, OR AN ADJACENT PAIR OF P AND THOSE OF Q, R AND T WHICH DO NOT REPRESENT A -OY GROUP FORM THE CHAINS -(CH2)4-, -(CH2)3-, -O(CH2)3-, -O(CH2)2-, -O(CH2)2O-, -CH2-CN(CH3)-O-, -CH=CH-O-, -CH=C(CH3)-O-, -OCH2O-, -NH-C(R4R5)-CH2-O-, -NR5(CH)2-O- OR -NR4(CH)2-NR4WHEREIN R4 IS HYDROGEN OR A LOWER ALKYL OR A LOWER ALKOXY GROUP AND R5 IS HYDROGEN, OR R4 AND R5 TOGETHER FORM AN =O GROUP, R1 IS SELECTED FROM THE HYDROGEN, ALKYL, ARYL AND ALKOXY CONTAINIG FROM 1 TO 10 CARBON ATOMS, AND PHARMACEUTICALLY ACCEPTABLE DERIVATIVES THEREOF, ARE VALUABLE IN THE TREATMENT OF DISEASES DUE TO ANTIGEN REACTIONS SUCH AS ASTHMA.

Inventors

• 👤 Hugh Cairns
• 👤 Richard Hazard
• 👤 John King

Bibliographic Details