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US4001280A Expired / Lapsed US ⏱️ 0.0 years remaining

Chromone derivatives

Assignee: Astellas Pharma Inc
•
Filing: 1973-06-20
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Granted: 1977-01-04
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Expires: 1993-06-20
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Abstract

Abstract Chromone derivatives of the formula: ##STR1## wherein R 1 is alkoxy, an N,S-containing heterocyclic group or aryloxy in which heterocyclic group may be substituted with halogen or acyl, and aryl may be substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy; R 2 is alkylene; R 3 is hydroxy, alkoxy or a group of the formula ##STR2## in which R 4 is hydrogen, R 5 is hydroxy or amino or R 4 and R 5 means taken together with the adjacent nitrogen atom, piperazinyl substituted with alkyl or hydroxyalkyl; provided that when R 3 is hydroxy or alkoxy, R 1 is an N,S-containing heterocyclic group or aryloxy in which heterocyclic group is substituted with halogen or acyl, and aryl is substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy, and nontoxic, pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents.

Inventors

  • 👤 Suminori Umio
  • 👤 Ikuo Ueda
  • 👤 Masaaki Matsuo
  • 👤 Masakazu Kobayashi
  • 👤 Osamu Nakaguti
  • 👤 Yoshinari Sato

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 11:57
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 44 words
A compound of the formula: ##STR31## wherein R 1 is aryloxy substituted with lower alkylenedioxy, said aryloxy being phenoxy, napthyloxy, tolyloxy, xylyloxy, mesityloxy or cumenyloxy; R 2 is lower alkylene; R 3 is hydroxy or lower alkoxy or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim 44 words
A compound of the formula: ##STR31## wherein R 1 is aryloxy substituted with lower alkylenedioxy, said aryloxy being phenoxy, napthyloxy, tolyloxy, xylyloxy, mesityloxy or cumenyloxy; R 2 is lower alkylene; R 3 is hydroxy or lower alkoxy or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim 11 words
A compound of claim 1 in which R 1 is 3,4-methylenedioxy-phenoxy.
Claim 4
Dependent Claim 12 words
A compound of claim 1 in which said compound is sodium 5-[2-(3,4-methylenedioxyphenoxy)ethoxy]chromone-2-carboxylate.
Claim 5
Dependent Claim 12 words
A compound of claim 1 in which said compound is ethyl 5-[2-(3,4-methylenedioxyphenoxy)ethoxy]chromone-2-carboxylate.

References Cited (Backward Citations)

US3427324A Cited
US3484445A Cited
US3629290A Cited
US3786071A Cited
US3882148A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-01-04 1980-07-05 1981-01-04 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-01-04 1984-07-05 1985-01-04 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-01-04 1988-07-05 1989-01-04 $7700.00 Window Closed / Lapsed

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