Patent US4273878A successfully refreshed from Google Patents.
Patent US3998790A successfully refreshed from Google Patents.
US3998790A
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US
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Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
Assignee: Hassle AB
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Filing: 1974-01-15
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Granted: 1976-12-21
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Expires: 1994-01-15
Abstract
Abstract Para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R' is an isopropyl or tertiarybutyl radical; Z is a member selected from the group consisting of -OR", -SR", and -NHCOOR", R" being a straight or branched lower alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3, are disclosed as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the β-receptors of the heart making them useful in treating heart diseases in animals including humans.
Inventors
- 👤 Arne Elof Brandstrom
- 👤 Per Arvid Emil Carlsson
- 👤 Stig Ake Ingemar Carlsson
- 👤 Hans Rudolf Corrodi
- 👤 Lars Ek
- 👤 Bengt Arne Hjalmar Ablad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138; A61K31/21; A61K31/27; A61P; A61P25/00; A61P25/02; A61P9/00; C; C07; C07C; C07C217/00; C07C217/02; C07C217/04; C07C217/28; C07C217/30; C07C217/32; C07C233/00; C07C233/01; C07C233/16; C07C233/17; C07C233/22; C07C317/00; C07C317/02; C07C317/10; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07D; C07D263/00; C07D263/02; C07D263/08; C07D263/16; C07D263/18; C07D263/20; C07D263/24; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/24; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
57 words
A compound of the formula ##STR21## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R' is an isopropyl or tertiary butyl radical; Z is a member selected from the group consisting of -OR", and -SR", R" being a straight or branched alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3.
Claim 2
Dependent Claim
57 words
A compound of the formula ##STR21## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R' is an isopropyl or tertiary butyl radical; Z is a member selected from the group consisting of -OR", and -SR", R" being a straight or branched alkyl radical having 1 to 3 carbon atoms; and n is 1, 2, or 3.
Claim 3
Dependent Claim
17 words
A compound according to claim 1 in racemic form and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 4
Dependent Claim
21 words
A compound according to claim 1 resolved into its optically active, levo-rotatory isomers and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 5
Dependent Claim
21 words
A compound according to claim 1 resolved into its optically active, dextro-rotatory isomer and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 wherein R' is isopropyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 1 wherein Z is -OR".
Claim 8
Dependent Claim
10 words
A compound according to claim 1 wherein Z is -SR".
Claim 9
Dependent Claim
12 words
A compound according to claim 5 wherein Z is -OR" or -SR".
Claim 10
Dependent Claim
14 words
The compound of claim 1 (±)-1-isopropylamino-3-[p-(β-methoxyethylphenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 11
Dependent Claim
14 words
The compound of claim 1 (-)-1-isopropylamino-3-[p-(β-methoxyethylphenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 12
Dependent Claim
14 words
The compound of claim 1 (+0-1-isopropylamino-3-[p-(β-methoxyethylphenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 13
Dependent Claim
14 words
The compound of claim 1 (±)-1-isopropylamino-3-[p-(β-ethoxyethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 14
Dependent Claim
14 words
The compound of claim 1 (-)-1-isopropylamino-3-[p-(β-ethoxyethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 15
Dependent Claim
14 words
The compound of claim 1 (+)-1-isopropylamino-3-[p-(β-ethoxyethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 16
Dependent Claim
14 words
The compound of claim 1 (±)-1-isopropylamino-3-[p-(ethoxymethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 17
Dependent Claim
14 words
The compound of claim 1 (-)-1-isopropylamino-3-[p-(ethoxymethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 18
Dependent Claim
14 words
The compound of claim 1 (+)-1-isopropylamino-3-[p-ethoxymethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 19
Dependent Claim
9 words
The compound of claim 1 wherein R' is tert.-butyl.
Claim 20
Dependent Claim
14 words
The compound of claim 1 (±)-1-isopropylamino-3-[p-(β-methylmercaptoethyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
Claim 21
Dependent Claim
14 words
The compoud of claim 1 (±)-1-isopropylamino-3-[p-(γ-methoxypropyl)-phenoxy]-propanol-2 and pharmaceutically acceptable, non-toxic acid addition salts thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-21 | 1980-06-21 | 1980-12-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-21 | 1984-06-21 | 1984-12-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-21 | 1988-06-21 | 1988-12-21 | $7700.00 | Window Closed / Lapsed |