1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes

Abstract

Abstract RACEMIC MIXTURES OF A COMPOUND OF THE FORMULA (R1,R2,R3-PHENYL)-O-CH2-CH(-OH)-CH2-NH-C<(-(CH2)N-)-R WHEREIN R IS ALKYL OF 1 TO 5 CARBON ATOMS, R1 IS CYANO, CARBOXYL, HYDROXYL, AMINO, NITRO, TRIFLUOROMETHYL, ALKYL OF UP TO 5 CARBON ATOMS, ALKENYL OF UP TO 5 CARBON ATOMS, ALKINYL OF UP TO 5 CARBON ATOMS, ALKOXY OF UP TO 5 CARBON ATOMS, ALKENYLOXY OF UP TO 5 CARBON ATOMS, ALKINYLOXY OF UP TO 5 CARBON ATOMS, HYDROXYALKYL OF UP TO 5 CARBON ATOMS, ALKOXYALKLY OF UP TO 5 CARBON ATOMS, AMINOALKYL OF UP TO 5 CARBON ATOMS, ALKYLAMINOALKYL OF UP TO 5 CARBON ATOMS, DIALKYLAMINOALKYL OF UP TO 5 CARBON ATOMS, ALKYLAMINO OF UP TO 5 CARBON ATOMS, CYANO (ALKYL OF UP TO 5 CARBON ATOMS), ALKOXY OF UP TO 5 CARBON ATOMS) CARBONYL, ALKYL OF UP TO 5 CARBON ATOMS) AMINO-CARBONYL, ALKYLTHIO OF UP TO 5 CARBON ATOMS, ACYLOXY OF UP TO 5 CARBON ATOMS, ACYLAMINO OF UP TO 5 CARBON ATOMS, ARYL OF UP TO 10 CARBON ATOMS, ARALKYL OF UP TO 10 CARBON ATOMS, ARYLOXY OF UP TO 10 CARBON ATOMS, ARALKOXY OF UP TO 10 CARBON ATOMS, ARYLAMINO OF UP TO 10 CARBON ATOMS OR HALOGEN, R2 IS HYDROGEN, HALOGEN, CYANO, ALKYL OF UP TO 5 CARBON ATOMS, AKOXY OF UP TO 5 CARBON ATOMS OR ALKNYL OF UP TO 5 CARBON ATOMS, R1 AND R2, TOGETHER WITH EACH OTHER, ARE 3,4-METHYLENEDIOXY, R3 IS HYDROGEN, HALOGEN, ALKYL OF UP TO 5 CARBON ATOMS OR ALKOXY OF UP TO 5 CARBON ATOMS, AND N IS AN INTEGER FROM 2 TO 7, INCLUSIVE, OPTICALLY ACTIVE COMPONENTS THEREOF, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS OF SAID RACEMIC AND OPTICALLY ACTIVE COMPOUNDS, USEFUL AS B-ADRENERGIC RECEPTOR BLOCKING AGENTS IN WARM-BLOODED ANIMALS.

Inventors

• 👤 H Koppe
• 👤 W Kummer
• 👤 A Engelhardt
• 👤 W Traunecker
• 👤 H Stahle
• 👤 K Zeile

Bibliographic Details