Patent US3989382A successfully refreshed from Google Patents.
US3989382A
Expired / Lapsed
US
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Platelet aggregation monitoring device
Assignee: Bio Data Corp
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Filing: 1975-01-22
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Granted: 1976-11-02
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Expires: 1995-01-22
Abstract
Abstract A difference amplifier continuously generates a signal representing the difference between the optical densities of a platelet rich and a platelet poor sample of blood plasma. A variable gain amplifier multiplies the difference signal by a factor which is proportional to the initial difference signal. Electronic circuitry automatically determines the multiplying factor by comparing the initial difference signal to a predetermined magnitude. The multiplied difference signal is continuously recorded on a chart recorder and an optional filter circuit is provided for selectively filtering the difference signal.
Inventors
- 👤 Frederick M. Kent
- 👤 Michael Sokol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:42
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/27; G01N21/272; G01J; G01J1/00; G01J1/10; G01J1/16; G01J1/1626; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4905
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
94 words
A platelet aggregation monitoring device comprising: means for continuously generating a signal representing the difference in the optical densities of a platelet rich plasma sample and a platelet poor plasma sample; means for multiplying said signal by a variable factor; means for automatically adjusting said factor such that said multiplied signal is initially equal to a preselected standard value, whereby the sensitivity of the device is automatically adjusted; and means for maintaining said factor constant once it has been adjusted to the point that said multiplied signal is equal to said preselected standard value.
Claim 2
Dependent Claim
94 words
A platelet aggregation monitoring device comprising: means for continuously generating a signal representing the difference in the optical densities of a platelet rich plasma sample and a platelet poor plasma sample; means for multiplying said signal by a variable factor; means for automatically adjusting said factor such that said multiplied signal is initially equal to a preselected standard value, whereby the sensitivity of the device is automatically adjusted; and means for maintaining said factor constant once it has been adjusted to the point that said multiplied signal is equal to said preselected standard value.
Claim 3
Dependent Claim
21 words
A platelet aggregation monitoring device as claimed in claim 1 further including means for recording the output of said multiplying means.
Claim 4
Dependent Claim
29 words
A platelet aggregation monitoring device as claimed in claim 1 wherein said multiplying means comprises a variable gain amplifier and a means for varying the gain of said amplifier.
Claim 5
Dependent Claim
21 words
A platelet aggregation monitoring device as claimed in claim 3 wherein said means for varying said gain includes variable resistance means.
Claim 6
Dependent Claim
43 words
A platelet aggregation monitoring device as claimed in claim 4 wherein said variable gain amplifier includes a feedback path and wherein said variable resistance means includes a plurality of resistors and further including means for selectively connecting said resistors to said feedback path.
Claim 7
Dependent Claim
48 words
A platelet aggregation monitoring device as claimed in claim 1 wherein said adjusting means includes a comparator means and wherein said maintaining means includes means responsive to said comparator means for preventing further adjustment of said factor once said multiplied signal is equal to said preselected standard value.
Claim 8
Dependent Claim
25 words
A platelet aggregation monitoring device as claimed in claim 1 wherein said means for adjusting said factor increases said factor in a step wise manner.
Claim 9
Dependent Claim
55 words
A platelet aggregation monitoring device as claimed in claim 1 wherein said means for continuously generating said signal comprises a difference amplifier, said difference amplifier having a first input connected to a photosensitive means associated with said platelet rich sample and a second input connected to a photosensitive means associated with said platelet poor sample.
Claim 10
Dependent Claim
34 words
A platelet aggregation monitoring device as claimed in claim 8 further including a filter means and means for selectively placing said filter means between the output of said difference amplifier and said first input.
Claim 11
Dependent Claim
51 words
A platelet aggregation monitoring device as claimed in claim 9 wherein said filter means includes a capacitor and further including means for charging said capacitor with the voltage received at said first input when said filter means is not placed between said output and said first input of said difference amplifier.
Claim 12
Dependent Claim
126 words
A platelet aggregation monitoring device comprising: means for generating a first signal representing the optical density of a platelet rich plasma sample; means for generating a second signal representing the optical density of a platelet poor plasma sample; means for generating a third signal proportional to the difference between said first and said second signal; means for multiplying said third signal by a variable factor; means for comparing said multiplied third signal to a preselected standard value; means for automatically varying said factor until said comparator means senses that said multiplied third signal is equal to said standard value; and means for automatically maintaining said factor constant after it has been varied to the point that said multiplied third signal is equal to said standard value.
Claim 13
Dependent Claim
126 words
A platelet aggregation monitoring device comprising: means for generating a first signal representing the optical density of a platelet rich plasma sample; means for generating a second signal representing the optical density of a platelet poor plasma sample; means for generating a third signal proportional to the difference between said first and said second signal; means for multiplying said third signal by a variable factor; means for comparing said multiplied third signal to a preselected standard value; means for automatically varying said factor until said comparator means senses that said multiplied third signal is equal to said standard value; and means for automatically maintaining said factor constant after it has been varied to the point that said multiplied third signal is equal to said standard value.
Claim 14
Dependent Claim
21 words
A platelet aggregation monitoring device as claimed in claim 11 further including means for recording the output of said multiplying means.
Claim 15
Dependent Claim
24 words
A platelet aggregation monitoring device as claimed in claim 11 wherein said means for varying said factor increases said factor in a stepwise manner.
References Cited (Backward Citations)
US3089382A
Cited
US3658480A
Cited
US3711774A
Cited
US3809482A
Cited
US3879135A
Cited
US3861877A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-02 | 1980-05-03 | 1980-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-02 | 1984-05-03 | 1984-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-02 | 1988-05-03 | 1988-11-02 | $7700.00 | Window Closed / Lapsed |