Patent US3979395A successfully refreshed from Google Patents.
US3979395A
Expired / Lapsed
US
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Process for the preparation of vincamine and other indole alkaloids
Assignee: Buskine SA
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Filing: 1975-08-06
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Granted: 1976-09-07
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Expires: 1995-08-06
Abstract
Abstract The invention relates to the preparation of vincamine and similar indole alkaloids, capable of being easily converted to vincamine, by oxydating a starting alkaloid selected between tabersonine and vincadifformine with oxygen, the reaction mixture being added with an essential amount of an inorganic or organic salt of a metal selected among Cu, Fe and Co.
Inventors
- 👤 Ida Taccone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:47
CPC Classifications
C; C07; C07D; C07D461/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
101 words
A method for the preparation of vincamine and similar indole alkaloids, starting from tabersonine or vincadifformine, characterized in that the starting compound, as a solution in a polar solvent, is added, in the ratio of 1:1 to 1:5 by weight of the starting alkaloid, with an inorganic or organic salt, soluble in the reaction medium, of a metal selected among Cu, Fe and Co, said metal being at the highest valence state thereof, the reaction being carried out in the presence of oxygen, at a temperature of between 10° and 50°C and for a time of between 5 and 15 days.
Claim 2
Independent Claim
101 words
A method for the preparation of vincamine and similar indole alkaloids, starting from tabersonine or vincadifformine, characterized in that the starting compound, as a solution in a polar solvent, is added, in the ratio of 1:1 to 1:5 by weight of the starting alkaloid, with an inorganic or organic salt, soluble in the reaction medium, of a metal selected among Cu, Fe and Co, said metal being at the highest valence state thereof, the reaction being carried out in the presence of oxygen, at a temperature of between 10° and 50°C and for a time of between 5 and 15 days.
Claim 3
Dependent Claim
17 words
A method according to claim 1, characterized in that the reaction is carried out in acid environment.
Claim 4
Dependent Claim
15 words
A method according to claim 1, characterized in that said metal salt is cupric sulphate.
Claim 5
Dependent Claim
15 words
A method according to claim 1, characterized in that said metal salt is ferric chloride.
Claim 6
Dependent Claim
21 words
A method according to claim 1, characterized in that said metal salt is a salt of cobalt of a monocarboxylic acid.
Claim 7
Dependent Claim
22 words
A method according to claim 2, characterized in that said acid environment is obtained by using the hydrochloride of the starting alkaloid.
Claim 8
Dependent Claim
26 words
A method according to claim 2, characterized in that said acid environment is obtained by adding an inorganic acid in aqueous solution to the reaction mixture.
Claim 9
Dependent Claim
26 words
A method according to claim 1, characterized in that said polar solvent is selected in the group consisting of alcohols, hydro-alcoholic mixtures, acrylonitrile, dimethyl-formamide and hexamethylenphosphortriamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-07 | 1980-03-08 | 1980-09-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-07 | 1984-03-08 | 1984-09-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-07 | 1988-03-08 | 1988-09-07 | $7700.00 | Window Closed / Lapsed |