US3884927A
Expired / Lapsed
US
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Process for the preparation of vincamine
Assignee: Sanofi Aventis France
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Filing: 1973-03-27
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Granted: 1975-05-20
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Expires: 1993-03-27
Abstract
Abstract Process for the preparation of vincamine wherein eburnamonine is reacted with an ethynylmagnesium halide to give (20 Alpha ,21 Alpha ) 16 Alpha -ethynyl eburnane 16 Beta -ol, which upon oxidation to vincaminic acid and subsequent methylation provides vincamine. The optically active forms of vincamine can be obtained by using an optically active form of eburnamonine.
Inventors
- 👤 Jacques Martel
- 👤 Germain Costerousse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:51
CPC Classifications
C; C07; C07D; C07D461/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
54 words
A PROCES FOR THE PREPARATION OF VINCAMINE, WHICH COMPRISES: A. REACTING EBURNAMONINE WITH AN ETHYNYLMAGNESIUM HALIDE TO GIVE (20Z,21A) 16A-ETHYNYL EBURNANE 16B-OL; B. REACTING THE (20A,21A) 16A-ETHNYNL EBURNANE 16B-OL; WITH AN OXIDIZING AGENT TO GIVE VINCAMINIC ACID; C. TREATING THE VINCAMINIC ACID WITH A METHYLATING AGENT TO GIVE VINCAMINE; AND C. ISOLATING THE VINCAMINE.
Claim 2
Dependent Claim
54 words
A PROCES FOR THE PREPARATION OF VINCAMINE, WHICH COMPRISES: A. REACTING EBURNAMONINE WITH AN ETHYNYLMAGNESIUM HALIDE TO GIVE (20Z,21A) 16A-ETHYNYL EBURNANE 16B-OL; B. REACTING THE (20A,21A) 16A-ETHNYNL EBURNANE 16B-OL; WITH AN OXIDIZING AGENT TO GIVE VINCAMINIC ACID; C. TREATING THE VINCAMINIC ACID WITH A METHYLATING AGENT TO GIVE VINCAMINE; AND C. ISOLATING THE VINCAMINE.
Claim 3
Dependent Claim
28 words
The process of claim 1 wherein the eburnamonine, the (20 Alpha ,21 Alpha ) 16 Alpha -ethynyl eburnane 16 Beta -ol; and the vincaminic acid are optically active.
Claim 4
Dependent Claim
59 words
The process of claim 2 wherein the vincamine is (+)-vincamine, the eburnamonine is (-)-eburnamonine, the (20 Alpha , 21 Alpha ) 16 Alpha -ethynyl eburnane 16 Beta -ol is (+)-(20 Alpha ,21 Alpha ) 16 Alpha -ethynyl eburnane 16 Beta -ol, the ethynylmagnesium halide is ethynylmagnesium bromide, the oxidizing agent is potassium permanganate, and the methylating agent is diazomethane.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-19 | 1978-11-18 | 1979-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-19 | 1982-11-18 | 1983-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-19 | 1986-11-18 | 1987-05-20 | $7700.00 | Window Closed / Lapsed |