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US3971791A
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2-Amino-1,4-dihydropyridine derivatives
Assignee: Bayer AG
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Filing: 1975-05-06
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Granted: 1976-07-27
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Expires: 1995-05-06
Abstract
Abstract 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.
Inventors
- 👤 Horst Meyer
- 👤 Friedrich Bossert
- 👤 Wulf Vater
- 👤 Kurt Stoepel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:58
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; C07D405/00; C07D405/02; C07D405/04; C07D409/00; C07D409/02; C07D409/04
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
66 words
A compound of the formula: ##SPC2## wherein R is thienyl or furyl, unsubstituted or substituted by one or two members selected from the group consisting of lower alkyl, lower alkoxy and halogeno; R 1 and R 2 together are alkylene of 2 to 4 carbon atoms; and R 3 lower alkyl, lower alkoxy, lower alkoxy(lower alkoxy), lower alkenyloxy, lower alkynyloxy, amino, lower alkylamino or di(lower alkyl)amino.
Claim 2
Dependent Claim
66 words
A compound of the formula: ##SPC2## wherein R is thienyl or furyl, unsubstituted or substituted by one or two members selected from the group consisting of lower alkyl, lower alkoxy and halogeno; R 1 and R 2 together are alkylene of 2 to 4 carbon atoms; and R 3 lower alkyl, lower alkoxy, lower alkoxy(lower alkoxy), lower alkenyloxy, lower alkynyloxy, amino, lower alkylamino or di(lower alkyl)amino.
Claim 3
Dependent Claim
58 words
A compound according to claim 1 which has the formula: ##SPC3## wherein R is thienyl or furyl, unsubstituted or substituted by one or two members selected from the group consisting of lower alkyl, lower alkoxy and halogeno; and R 3 is lower alkyl, lower alkoxy, lower alkoxy(lower alkoxy), lower alkenyloxy, lower alkynyloxy, amino, lower alkylamino or di(lower alkyl)amino.
Claim 4
Dependent Claim
16 words
A compound according to claim 2 wherein R is furyl and R 3 is lower alkoxy.
Claim 5
Dependent Claim
16 words
A compound according to claim 2 wherein R is thienyl and R 3 is lower alkoxy.
References Cited (Backward Citations)
US3441648A
Cited
US3574843A
Cited
US3644627A
Cited
US3455945A
Cited
US3862161A
Cited
US3856798A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |