Abstract Novel substituted polyamides of the general formula ##EQU1## wherein A and B, which may be identical or different, are the hydrocarbon backbone groups of the formula --(CH 2 ) n --, where n is an integer, R 2 and R 3 are the residues of an aldehyde R 2 --CHO or of an isocyanide R 3 --N.tbd.C, where R 2 and R 3 are aliphatic, aromatic or heterocyclic residues of the respective aldehyde or isocyanide, or where R 3 is a chromophoric moiety. R 2 and R 3 can be substituted, and amongst the possible substituents there may be R 3 designating --(CH 2 ) n --NHCO--CHR 2 --N(CO)(R 4 )--X, where R 4 is the residue of a monocarboxylic or dicarboxylic acid and X is the lysyl residue of a protein, which may be biologically active, or the residue of a low-molecular weight compound containing a primary amine moiety. Preferred polyamides are various types of nylons. Amongst proteins chemically bound to the polyamide there may be mentioned enzymes, antibodies and peptide hormones. When R 3 is a chromophoric moiety, the product is a chemically dyed polyamide. The invention relates also to a process for the production of such novel substituted polyamides.
Inventors
👤 Mordechai Sokolovsky
👤 Amihay Freeman
👤 Leon Goldstein
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-10-24 13:47
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/48
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
145 words
A process for preparing substituted polyamides of the general formula ##EQU6## wherein A and B, which may be identical or different, are the hydrocarbon backbone groups of the general formula --(CH 2 ) n --, where n is an integer, R 2 and R 3 are residues of an aldehyde R 2 -CHO or an isocyanide R 3 -N.tbd.C, where said aldehyde is an aliphatic aldehyde and said isocyanide is a diisocyanoalkane, which comprises: a. partially hydrolyzing the amide bonds on the surface of a polyamide; and b. resealing the carboxy- and amino- groups formed by said hydrolysis by reacting with said aldehyde, R 2 -CHO, and with said isocyanide, R 3 -N.tbd.C, resulting in a polyamide of a molecular weight substantially identical with that of the starting material before the partial hydrolysis, substituted by side-chains on the nitrogen of the newly formed peptide bond.
Claim 2
Dependent Claim
145 words
A process for preparing substituted polyamides of the general formula ##EQU6## wherein A and B, which may be identical or different, are the hydrocarbon backbone groups of the general formula --(CH 2 ) n --, where n is an integer, R 2 and R 3 are residues of an aldehyde R 2 -CHO or an isocyanide R 3 -N.tbd.C, where said aldehyde is an aliphatic aldehyde and said isocyanide is a diisocyanoalkane, which comprises: a. partially hydrolyzing the amide bonds on the surface of a polyamide; and b. resealing the carboxy- and amino- groups formed by said hydrolysis by reacting with said aldehyde, R 2 -CHO, and with said isocyanide, R 3 -N.tbd.C, resulting in a polyamide of a molecular weight substantially identical with that of the starting material before the partial hydrolysis, substituted by side-chains on the nitrogen of the newly formed peptide bond.
Claim 3
Dependent Claim
18 words
A process as claimed in claim 1, wherein said aliphatic aldehyde is acetaldehyde and the product is PIN-polyamide.
Claim 4
Dependent Claim
17 words
A process as claimed in claim 2, wherein the polyamide is nylon and the product is PIN-nylon.
Claim 5
Dependent Claim
12 words
A process as claimed in claim 1, wherein sad diisocyanoalkane is 1,6-diisocyanohexane.