Patent US3965255A successfully refreshed from Google Patents.
US3965255A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled drug releasing preparations
Assignee: Eljim E E Ecology Ltd
•
Filing: 1974-05-01
•
Granted: 1976-06-22
•
Expires: 1994-05-01
Abstract
Abstract A drug delivery preparation with controlled release time and rate, comprising a therapeutic agent being encapsulated in or coated by a solvent membrane, as well as a process for the manufacture thereof, are disclosed.
Inventors
- 👤 Rene Bloch
- 👤 Ora Kedem
- 👤 Ester Lobel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/282; A61K9/2833; A61K9/284
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
148 words
A zero order release rate drug releasing preparation adapted for oral administration and for the controlled release of the drug contained therein at a substantially constant release rate during the first hour after administration and for several hours thereafter, which preparation comprises a drug body encapsulated in or coated with an outer solvent member, said drug body being selected from the group consisting of pure drug and drug admixed with an additional substance or substances which do not substantially influence the zero order release rate of the drug in said drug releasing preparation, and said solvent membrane comprising at least one plasticizer and at least one reinforcing polymer, which membrane is essentially insoluble in the digestive tract, the plasticizer content constituting from about 40 to about 90% by weight of the solvent membrane, said solvent membrane in the as prepared drug releasing preparation being substantially free of drug.
Claim 2
Dependent Claim
148 words
A zero order release rate drug releasing preparation adapted for oral administration and for the controlled release of the drug contained therein at a substantially constant release rate during the first hour after administration and for several hours thereafter, which preparation comprises a drug body encapsulated in or coated with an outer solvent member, said drug body being selected from the group consisting of pure drug and drug admixed with an additional substance or substances which do not substantially influence the zero order release rate of the drug in said drug releasing preparation, and said solvent membrane comprising at least one plasticizer and at least one reinforcing polymer, which membrane is essentially insoluble in the digestive tract, the plasticizer content constituting from about 40 to about 90% by weight of the solvent membrane, said solvent membrane in the as prepared drug releasing preparation being substantially free of drug.
Claim 3
Dependent Claim
22 words
A drug releasing preparation according to claim 1, wherein plasicizer is 2-Ethyl-hexyl-diphenyl phosphate and the polymer reinforcing said plasticizer is polyvinyl chloride.
Claim 4
Dependent Claim
16 words
A drug releasing preparation according to claim 1, wherein the reinforcing polymer is a thermoplastic polymer.
Claim 5
Dependent Claim
21 words
A drug releasing preparation according to claim 3, wherein the polymer is selected from the group consisting of polyvinylchloride and polyvinylacetate.
Claim 6
Dependent Claim
23 words
A drug releasing preparation according to claim 1, wherein the plasticiser is selected from the group consisting of adipates, sebacates, phosphates and phthalates.
Claim 7
Dependent Claim
48 words
A drug releasing preparation according to claim 4 wherein the plasticiser is selected from the group consisting of butyl-phthalyl-butyl-glycolate, epoxidised soy bean oil, tritolyl-phosphate, dibutyl sebacate, dioctyl sebacate, tri-(diethyl-hexyl)-phosphate, 2-ethyl-hexyl-diphenyl phosphate, di-iso-butyl-adipate, methyl stearate, glycerol glyceryl monooleate, butyl-benzyl phthalate, dioctyl phthalate, diphenyl-octyl phosphate, diethyl phthalate, di-(2-ethyl-hexyl)-phthalate and TBP.
Claim 8
Dependent Claim
26 words
A drug releasing preparation according to claim 1, wherein the plasticiser content is at least about 80% by weight of the weight of the solvent membrane.
Claim 9
Dependent Claim
28 words
A drug releasing preparation according to claim 1, wherein the therapeutic agent is selected from the group consisting of steroids, vitamins, antihistamines, stimulants, tranquilizers. antibiotics and arrhytmic agents.
Claim 10
Dependent Claim
32 words
A drug releasing preparation according to claim 8, wherein the therapeutic agent is selected from the group consisting of digitalis, antipyrine, procainamide hydrochloride, atropine sulfate, theophylline and dicumarol, diazepam, amitriptyline and dehydroemetine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-22 | 1979-12-22 | 1980-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-22 | 1983-12-22 | 1984-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-22 | 1987-12-22 | 1988-06-22 | $7700.00 | Window Closed / Lapsed |