Patent US3916026A successfully refreshed from Google Patents.
US3916026A
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Method for the preparation of gamma-globulin suitable for intravenous use
Assignee: Biotest Serum Institut GmbH
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Filing: 1973-12-05
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Granted: 1975-10-28
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Expires: 1993-12-05
Abstract
Abstract The present invention provides a process for the preparation of a non-complement-binding gamma-globulin suitable for intravenous application. A complement-binding gamma-globulin is treated with Beta -propiolactone. When the gamma-globulin solution being treated contains aggregates and/or hydrolases, these are preferably removed prior to treatment with one of the aforeidentified compounds. When they are removed, the effective amount of Beta -propiolactone is between about 0.01 and 0.043 ml. per gram of protein in the gamma-globulin. If they are not removed, the amount of Beta -propiolactone is increased ten-fold.
Inventors
- 👤 Wolfgang Stephan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 23:12
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
15 words
The process of claim 1, wherein said gamma-globulin solution is serum, plasma or standard gamma-globulin.
Claim 2
Dependent Claim
17 words
The process of claim 2, wherein said serum or plasma is human serum, plasma or standard gamma-globulin.
Claim 3
Dependent Claim
60 words
In the intravenous application of gamma-globulin, comprising the steps of preparing a gamma-globulin solution and thereafter intravenously injecting it, the improvement which comprises admixing an aqueous complement-binding hydrolase-containing gamma-globulin solution with about 0.1 to 0.43 ml of Beta -propiolactone per gram of protein in said gamma-globulin solution, whereby said solution may be stored for a prolonged period prior to injection.
Claim 4
Dependent Claim
60 words
In the intravenous application of gamma-globulin, comprising the steps of preparing a gamma-globulin solution and thereafter intravenously injecting it, the improvement which comprises admixing an aqueous complement-binding hydrolase-containing gamma-globulin solution with at least about 0.43 ml of Beta -propiolactone per gram of protein in said gamma-globulin solution, whereby said solution may be stored for a prolonged period prior to injection.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-27 | 1979-04-28 | 1979-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-27 | 1983-04-28 | 1983-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-27 | 1987-04-28 | 1987-10-28 | $7700.00 | Window Closed / Lapsed |