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US3914408A
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Vaccine for neonatal calf diarrhea
Assignee: University of Nebraska–Lincoln
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Filing: 1974-11-29
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Granted: 1975-10-21
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Expires: 1994-11-29
Abstract
Abstract A vaccine is prepared by passaging a coronavirus-like agent in tissue culture or by inactivating the viral agent. The vaccine is useful for immunizing bovine animals against calf diarrhea.
Inventors
- 👤 Charles A Mebus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:07
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/215; A61K2039/51; A61K2039/525; A61K2039/5252; A61K2039/5254; A61K2039/54; A61K2039/541; A61K2039/542; A61K2039/55; A61K2039/552; A61K2039/555; A61K2039/55505; A61K2039/70; C; C12; C12N; C12N2720/00; C12N2720/00011; C12N2720/12011; C12N2720/12311; C12N2720/12334; C12N2770/00; C12N2770/00011; C12N2770/20011; C12N2770/20034; Y; Y10; Y10S; Y10S424/00; Y10S424/813
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
36 words
A COMBINATION PARENTAL CALF DIARRHEA VACCINE COMPRISING AN IMMUNIZING-EFFECTIVE AMOUNT OF AN INACTIVATED BOVINE CELL CULTURE PROPAGATED CORONAVIRUS-LIKE CALF DIARRHEA VIRUS AND AN IMMUNIZING-EFFECTIVE AMOUNT OF AN INACTIVATED BOVINE CELL CULTURE PROPAGATED REOVIRUS-LIKE CALF DIARRHEA VIRUS.
Claim 2
Dependent Claim
36 words
A COMBINATION PARENTAL CALF DIARRHEA VACCINE COMPRISING AN IMMUNIZING-EFFECTIVE AMOUNT OF AN INACTIVATED BOVINE CELL CULTURE PROPAGATED CORONAVIRUS-LIKE CALF DIARRHEA VIRUS AND AN IMMUNIZING-EFFECTIVE AMOUNT OF AN INACTIVATED BOVINE CELL CULTURE PROPAGATED REOVIRUS-LIKE CALF DIARRHEA VIRUS.
Claim 3
Dependent Claim
76 words
A method for immunizing a newborn calf against neonatal calf diarrhea caused by a coronavirus-like or reovirus-like calf diarrhea virus comprising parenterally administering at least 1 ml. of the combination vaccine claimed in claim 1 to either an adult pregnant cow 30 to 90 days prior to the birth of said newborn calf and causing the said calf to ingest the colostrum or milk containing protective antibodies or to the said newborn calf soon after birth.
Claim 4
Dependent Claim
17 words
A vaccine according to claim 1, in which the amounts of the two viruses are approximately equal.
Claim 5
Dependent Claim
12 words
A vaccine according to claim 1, in which an adjuvant is present.
Claim 6
Dependent Claim
20 words
A vaccine according to claim 1, in which the adjuvant is aluminum hydroxide gel, potassium alum, alginate, or mineral oil.
Claim 7
Dependent Claim
15 words
A vaccine according to claim 1, in which both viruses have been inactivated with formalin.
Claim 8
Dependent Claim
37 words
A vaccine according to claim 1, in which the coronavirus-like virus has been attenuated by about 27 passages in bovine kidney cells and the reovirus-like virus has been attenuated by about 201 passages in bovine kidney cells.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-20 | 1979-04-21 | 1979-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-20 | 1983-04-21 | 1983-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-20 | 1987-04-21 | 1987-10-21 | $7700.00 | Window Closed / Lapsed |