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US3911008A
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Polar-substituted propanolamines as anti-angina and anti-hypertensive agents
Assignee: Pfizer Inc
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Filing: 1974-08-15
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Granted: 1975-10-07
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Expires: 1994-08-15
Abstract
Abstract A novel process for the synthesis of substituted propanolamines from N-substituted aziridines.
Inventors
- 👤 Michael N Edinberry
- 👤 Grant W Mclay
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:12
CPC Classifications
C; C07; C07D; C07D203/00; C07D203/04; C07D203/06; C07D203/08; C07D203/10
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
8 words
A PROCESS FOR PREPARING PROPANOLAMINE DERIVATIVES OF THE
Claim 2
Dependent Claim
8 words
A PROCESS FOR PREPARING PROPANOLAMINE DERIVATIVES OF THE
Claim 3
Dependent Claim
47 words
The process of claim 1 in which the reaction is carried out in a reaction inert solvent in the presence of a basic or acidic catalyst using approximately equimolar proportions of the reactants at a temperature of from 20* to 150*C for from 2 to 24 hours.
Claim 4
Dependent Claim
27 words
A process as claimed in claim 2, wherein the solvent is amyl alcohol and the catalyst is triethylamine and the reaction is carried out at reflux temperature.
Claim 5
Dependent Claim
17 words
The process of claim 3 wherein said N-substituted aziridine is 1-(2-hydroxy-3-(2-tolyloxy)propyl)aziridine and said substituted phenol is p-hydroxybenzamide.
Claim 6
Dependent Claim
17 words
The process of claim 3 wherein said N-substituted aziridine is 1-(2-hydroxy-3-(2-methoxyphenoxy)propyl)aziridine and said substituted phenol is p-hydroxybenzamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-06 | 1979-04-07 | 1979-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-06 | 1983-04-07 | 1983-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-06 | 1987-04-07 | 1987-10-07 | $7700.00 | Window Closed / Lapsed |