Integrated device for administering beneficial drug at programmed rate

Claim 2

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. bioerodible container providing an internal space therein, b. a delivery device housed in the container, the device comprising, c. a beneficial agent, d. a reservoir containing the beneficial agent, said reservoir formed of a solid polymeric release rate controlling biologically acceptable imperforate material permeable to the passage of the agent by diffusion, the reservoir joined to, d. a hollow deformable closed member, said member comprising a means for moving from a collapsed position to an expanded position on release of the device from the container and moving from an expanded position to a collapsed position after a period of agent release time, with agent metered from the reservoir in a therapeutically effective amount by diffusion for a prolonged period of time on release of the device from the container in the environment of use while the means is in an expanded position and thereafter the means moving to a collapsed position.

Claim 3

A delivery device for the controlled and continuous release of agent according to claim 1 wherein the hollow deformable member is provided with a bioerodible plug that on bioerosion in a physiologic environment vents the interior of the member to its exterior.

Claim 4

A delivery device for the controlled and continuous release of agent according to claim 1 wherein the hollow deformable member is formed of an elastic material permeable to a gas that slowly diffuses through the material to move the member from an expanded position to a collapsed position.

Claim 5

A delivery device for the controlled and continuous release of agent according to claim 1 wherein the hollow deformable member contains a liquid means for producing a gas that has a vapor pressure above one atmosphere at ambient temperature.

Claim 6

A delivery device for the controlled and continuous release of an agent according to claim 1 wherein the reservoir contains an agent that produces a local effect.

Claim 7

A delivery device for the controlled and continuous administration of an agent according to claim 1 wherein the hollow deformable member is formed of a material that bioerodes at a physiological temperature in a physiological environment.

Claim 8

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. a beneficial agent, b. a reservoir containing the beneficial agent, said reservoir formed of a solid polymeric release rate controlling biologically acceptable imperforate material permeable to the passage of the agent by diffusion, the reservoir joined to, c. a hollow deformable closed member, said member for moving from a collapsed position to an expanded position in a preselected environment of use and for moving after release of agent from the device to a collapsed position for transit of device from the environment, with agent metered from the reservoir in a therapeutically effective amount for a prolonged period of time in the environment of use when the means is in the expanded position thereafter the means moving to a collapsed position.

Claim 9

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. a beneficial agent, b. a reservoir containing the beneficial agent, said reservoir formed of a solid polymeric release rate controlling biologically acceptable imperforate material permeable to the passage of the agent by diffusion, the reservoir joined to, c. a hollow deformable closed member, said member for moving from a collapsed position to an expanded position in a preselected environment of use and for moving after release of agent from the device to a collapsed position for transit of device from the environment, with agent metered from the reservoir in a therapeutically effective amount for a prolonged period of time in the environment of use when the means is in the expanded position thereafter the means moving to a collapsed position.

Claim 10

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. a bioerodible container providing an internal space therein, b. a delivery device housed in the container, the device comprising, c. a beneficial agent, d. a reservoir containing the beneficial agent, said reservoir formed of a polymeric microporous material containing the beneficial agent, whose micropores are a means for containing an agent release rate controlling medium permeable to the passage of the agent by diffusion, the reservoir joined to, e. a hollow deformable closed member, said member comprising a means for moving from a collapseD position to an expanded position on release of the device from the container and movable fron an expanded position to a collapsed position after a period of agent release time, with agent metered from the reservoir in a therapeutically effective amount by diffusion through the release rate controlling medium for a prolonged period of time on release of the device from the container in the environment of use while the means is in an expanded position and thereafter the means moving to a collapsed position.

Claim 11

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. a bioerodible container providing an internal space therein, b. a delivery device housed in the container, the device comprising, c. a beneficial agent, d. a reservoir containing the beneficial agent, said reservoir formed of a polymeric microporous material containing the beneficial agent, whose micropores are a means for containing an agent release rate controlling medium permeable to the passage of the agent by diffusion, the reservoir joined to, e. a hollow deformable closed member, said member comprising a means for moving from a collapseD position to an expanded position on release of the device from the container and movable fron an expanded position to a collapsed position after a period of agent release time, with agent metered from the reservoir in a therapeutically effective amount by diffusion through the release rate controlling medium for a prolonged period of time on release of the device from the container in the environment of use while the means is in an expanded position and thereafter the means moving to a collapsed position.

Claim 12

A delivery device for the controlled and continuous release of agent according to claim 1 wherein the hollow deformable member contains a liquid means for producing a gas that has a vapor pressure above one atmosphere at physiological temperature.

Claim 13

A delivery device for the controlled and continuous release of an agent according to claim 1 wherein the reservoir contains an agent that produces a systemic effect.

Claim 14

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. a beneficial agent, b. a reservoir containing the beneficial agent, said reservoir formed of a polymeric microporous solid material containing the beneficial agent, whose micropores are a means for containing a liquid release rate controlling medium permeable to the passage of the agent by diffusion, the reservoir joined to, c. a hollow deformable closed member, said member comprising a means for moving from a collapsed position to an expanded position in a preselected environment of use and for moving after release of agent from the device to a collapsed position for transit of device from the environment, d. and wherein agent is metered from the reservoir in a therapeutically effective amount by diffusion through the release rate controlling material for a prolonged period of time in the environment of use when the member is in the expanded position and thereafter the member moving to a collapsed position.

Claim 15

A delivery device for the controlled and continuous release of a beneficial agent, the device comprising in combination, a. a beneficial agent, b. a reservoir containing the beneficial agent, said reservoir formed of a polymeric microporous solid material containing the beneficial agent, whose micropores are a means for containing a liquid release rate controlling medium permeable to the passage of the agent by diffusion, the reservoir joined to, c. a hollow deformable closed member, said member comprising a means for moving from a collapsed position to an expanded position in a preselected environment of use and for moving after release of agent from the device to a collapsed position for transit of device from the environment, d. and wherein agent is metered from the reservoir in a therapeutically effective amount by diffusion through the release rate controlling material for a prolonged period of time in the environment of use when the member is in the expanded position and thereafter the member moving to a collapsed position.