US3786813A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery device with self actuated mechanism for retaining device in selected area
Assignee: Alza Corp
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Filing: 1972-12-27
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Granted: 1974-01-22
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Expires: 1992-12-27
Abstract
Abstract A device is disclosed for administering a drug at a controlled rate for a prolonged period of time to a drug receptor area to produce a nonsystemic or systemic physiological or pharmacological effect. The device is comprised of a hollow deformable member that is movable from a collapsed to an expanded position and returnable to a collapsed position after an extended period of time. A housing is attached to the deformable member and it is internally divided into a first and second chamber with the chambers separated by an impermeable, pressure responsive movable bladder. The first chamber contains a drug and it has a discharge port for releasing the drug to the exterior of the device. The second chamber contains a means for generating pressure that is applied against the bladder. Drug is released from the first chamber through the discharge port by the bladder moving in response to pressure generated in the second chamber to increase its volume while simultaneously reducing the volume of the first chamber to release the drug at a controlled rate over a prolonged period of time. The device is initially optionally contained in a bioerodible container that erodes in the area to release the container.
Inventors
- 👤 A Michaels
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:29
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
196 words
A drug delivery device for the controlled and continuous administration of a drug to an environment of use to produce a therapeutic effect comprising: a hollow expandable closed member having therein self-contained means for expanding the member and self-contained means for contracting the member after a given period of time of expansion, the member being affixed to drug delivering means for delivering a drug at a controlled rate over the given period of time, the delivering means comprising an outer housing defining an internal space including a first chamber and a second chamber, the first chamber containing drug and having in communication therewith discharge means for releasing the drug to the environment of use, the second chamber containing means for generating a pressure, with means for separating the chambers and transmitting the pressure generated in the second chamber to the drug in the first chamber being interposed between the two chambers, the pressure thereby causing a therapeutically effective amount of drug to be released from the first chamber through the discharge means for the given period of time while the member is in an expanded state, thereafter the means for contracting causing the member to contract.
Claim 2
Dependent Claim
196 words
A drug delivery device for the controlled and continuous administration of a drug to an environment of use to produce a therapeutic effect comprising: a hollow expandable closed member having therein self-contained means for expanding the member and self-contained means for contracting the member after a given period of time of expansion, the member being affixed to drug delivering means for delivering a drug at a controlled rate over the given period of time, the delivering means comprising an outer housing defining an internal space including a first chamber and a second chamber, the first chamber containing drug and having in communication therewith discharge means for releasing the drug to the environment of use, the second chamber containing means for generating a pressure, with means for separating the chambers and transmitting the pressure generated in the second chamber to the drug in the first chamber being interposed between the two chambers, the pressure thereby causing a therapeutically effective amount of drug to be released from the first chamber through the discharge means for the given period of time while the member is in an expanded state, thereafter the means for contracting causing the member to contract.
Claim 3
Dependent Claim
51 words
A drug delivery device for the controlled and continuous administration of drug according to claim 1 wherein the self-contained means for expanding the member comprises a liquid that vaporizes at physiological temperature to producE a gas which expands the hollow expandable closed member from a collapsed position to an expanded position.
Claim 4
Dependent Claim
39 words
A drug delivery device for the controlled and continuous administration of a drug according to claim 2 wherein the self-contained means for contracting the member comprises means for venting the interior of the member to the environment of use.
Claim 5
Dependent Claim
35 words
A drug delivery device for the controlled and continuous administration of drug according to claim 3 wherein the means for venting the interior of the member to the environment of use comprises a bioerodible plug.
Claim 6
Dependent Claim
48 words
A drug delivery device for the controlled and continuous administration of drug according to claim 3 wherein the means for venting comprises the hollow expandable closed member, the member being formed of a material that lets the gas slowly diffuse through the material to the environment of use.
Claim 7
Dependent Claim
66 words
A drug delivery device for the controlled and continuous administration of drug according to claim 2 wherein the hollow expandable member communicates with the second chamber, the means for generating a pressure in the second chamber comprises a means for producing a gas at physiological temperature, the gas expanding the member and also producing a pressure which is transmitted to the drug in the first chamber.
Claim 8
Dependent Claim
30 words
A drug delivery device for the controlled and continuous administration of drug according to claim 1 wherein the means for generating a pressure comprises means for generating an osmotic pressure.
Claim 9
Dependent Claim
22 words
A drug delivery device for the controlled and continuous administration of drug according to claim 1 additionally comprising an outer bioerodible container.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-01-21 | 1977-07-23 | 1978-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-01-21 | 1981-07-23 | 1982-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-01-21 | 1985-07-23 | 1986-01-22 | $7700.00 | Window Closed / Lapsed |