Patent US3868358A successfully refreshed from Google Patents.
US3868358A
Expired / Lapsed
US
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Protamine-insulin product
Assignee: Eli Lilly and Co
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Filing: 1973-03-02
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Granted: 1975-02-25
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Expires: 1993-03-02
Abstract
Abstract The invention relates to a combination of protamine with an insulin salt. The insulin salt is derived by crystallization of insulin in the presence of ions of an alkali metal or metalloid such as sodium, potassium, lithium, cesium or ammonium at an alkaline pH range. The protamine is present in an amount from about 0.2 to about 1.5 mg. of protamine for each 100 units of insulin. The insulin salt and protamine form an insoluble complex at a pH from 6.5 to 8 in an aqueous medium, which complex when dried is easily reconstituted without activity loss.
Inventors
- 👤 Richard L Jackson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 15:48
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/28
Claims Analysis
Total Claims: 1
Claim 1
Independent Claim
14 words
The composition of claim 1 wherein the insulin salt is the sodium insulin salt.
References Cited (Backward Citations)
US2694666A
Cited
US2801953A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-24 | 1978-08-26 | 1979-02-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-24 | 1982-08-26 | 1983-02-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-24 | 1986-08-26 | 1987-02-25 | $7700.00 | Window Closed / Lapsed |