Patent US3864089A successfully refreshed from Google Patents.
US3864089A
Expired / Lapsed
US
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Multiple-sample rotor assembly for blood fraction preparation
Assignee: United States Atomic Energy Commission
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Filing: 1973-12-10
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Granted: 1975-02-04
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Expires: 1993-12-10
Abstract
Abstract A multiple-sample centrifugal rotor for blood fraction preparation is described. The rotor assembly includes an inner disk-shaped portion defining a circular array of whole blood sample-receiving chambers. Blood samples are statically loaded into the respective chambers through static loading ports. Liquids for washing and hemolyzing the cell fractions are introduced to the chambers following recovery of the plasma fraction by means of a central dynamic distribution port and a multiplicity of distribution passageways extending between the dynamic distribution port and the centrifugal ends of respective chambers. Unloading of blood fractions and washing liquid is accomplished through transfer passageways extending from a point intermediate the centrifugal and centripetal ends of the chambers radially inward and then outward to the periphery of the inner disk-shaped rotor assembly portion. A removable outer rotor portion defining at least one collection chamber for receiving materials discharged from the transfer passageways is nested concentrically about the inner rotor assembly portion.
Inventors
- 👤 Thomas O Tiffany
- 👤 James C Mailen
- 👤 Wayne F Johnson
- 👤 Charles D Scott
- 👤 Jr W Wilson Pitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:10
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B; B04; B04B; B04B5/00; B04B5/04; G01N21/00; G01N21/01; G01N21/03; G01N21/07
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
224 words
A MULTIPLE-SAMPLE CENTRIFUGAL ROTOR ASSEMBLY FOR BLOOD FRACTION PREPARATION COMPRISING: A. AN INNER DISK-SHAPED ROTOR PORTION HAVING A TOP END SURFACE, SAID INNER ROTOR PORTION DEFINING: I. A MULTIPLICITY OF RADIALLY ORIENTED SAMPLE-RECEIVING CHAMBERS HAVING CENTRIPETAL AND CENTRIFUGAL ENDS, SAID SAMPLE-RECEIVING CHAMBERS BEING DISPOSED IN A CIRCULAR ARRAY; II. A MULTIPLICITY OF STATIC SAMPLE-LOADING PORTS, EACH OF SAID PORTS COMMUNICATING BETWEEN SAID TOP END SURFACE AND RESPECTIVE SAMPLE-RECEIVING CHAMBERS; III. A CENTRALLY LOCATED DYNAMIC DISTRIBUTION PORT OPEN TO SAID TOP END SURFACE; IV. A MULTIPLICITY OF DISTRIBUTION PASSAGEWAYS, EACH OF SAID DISTRIBUTION PASSAGEWAYS COMMUNICATING BETWEEN SAID DYNAMIC DISTRIBUTION PORT AND THE CENTRIFUGAL END OF A RESPECTIVE SAMPLE-RECEIVING CHAMBER; AND V. A MULTIPLICITY OF TRANSFER PASSAGEWAYS, EACH OF SAID TRANSFER PASSAGEWAYS COMMUNICATING BETWEEN ONE OF SAID SAMPLE-RECEIVING CHAMBERS AT A POINT INTERMEDITE ITS CENTRIFUGAL AND CENTRIPETAL ENDS AND THE RADIAL PERIPHERY OF SAID INNER ROTOR PORTION, EACH OF SAID TRANSFER PASSAGEWAYS EXTENDING RADIALLY INWARD FROM ITS POINT OF COMMUNICATION WITH SAID SAMPLE-RECEIVING CHAMBER AND THEN GENERALLY RADIALLY OUTWARD TO SAID RADIAL PERIPHERY OF SAID INNER ROTOR PORTION; AND B. A REMOVABLE OUTER ROTOR PORTION HAVING AN ANNULAR CONFIGURATION NESTED CONCENTRICALLY ABOUT SAID INNER ROTOR PORTION, SAID OUTER ROTOR PORTION DEFINING AT LEAST ONE COLLECTION CHAMBER IN FLUID COMMUNICATION WITH SAID TRANSFER PASSAGEWAYS IN SAID INNER ROTOR PORTION FOR RECEIVING MATERIAL DISCHARAGED FROM SAID TRANSFER PASSAGEWAYS.
Claim 2
Dependent Claim
224 words
A MULTIPLE-SAMPLE CENTRIFUGAL ROTOR ASSEMBLY FOR BLOOD FRACTION PREPARATION COMPRISING: A. AN INNER DISK-SHAPED ROTOR PORTION HAVING A TOP END SURFACE, SAID INNER ROTOR PORTION DEFINING: I. A MULTIPLICITY OF RADIALLY ORIENTED SAMPLE-RECEIVING CHAMBERS HAVING CENTRIPETAL AND CENTRIFUGAL ENDS, SAID SAMPLE-RECEIVING CHAMBERS BEING DISPOSED IN A CIRCULAR ARRAY; II. A MULTIPLICITY OF STATIC SAMPLE-LOADING PORTS, EACH OF SAID PORTS COMMUNICATING BETWEEN SAID TOP END SURFACE AND RESPECTIVE SAMPLE-RECEIVING CHAMBERS; III. A CENTRALLY LOCATED DYNAMIC DISTRIBUTION PORT OPEN TO SAID TOP END SURFACE; IV. A MULTIPLICITY OF DISTRIBUTION PASSAGEWAYS, EACH OF SAID DISTRIBUTION PASSAGEWAYS COMMUNICATING BETWEEN SAID DYNAMIC DISTRIBUTION PORT AND THE CENTRIFUGAL END OF A RESPECTIVE SAMPLE-RECEIVING CHAMBER; AND V. A MULTIPLICITY OF TRANSFER PASSAGEWAYS, EACH OF SAID TRANSFER PASSAGEWAYS COMMUNICATING BETWEEN ONE OF SAID SAMPLE-RECEIVING CHAMBERS AT A POINT INTERMEDITE ITS CENTRIFUGAL AND CENTRIPETAL ENDS AND THE RADIAL PERIPHERY OF SAID INNER ROTOR PORTION, EACH OF SAID TRANSFER PASSAGEWAYS EXTENDING RADIALLY INWARD FROM ITS POINT OF COMMUNICATION WITH SAID SAMPLE-RECEIVING CHAMBER AND THEN GENERALLY RADIALLY OUTWARD TO SAID RADIAL PERIPHERY OF SAID INNER ROTOR PORTION; AND B. A REMOVABLE OUTER ROTOR PORTION HAVING AN ANNULAR CONFIGURATION NESTED CONCENTRICALLY ABOUT SAID INNER ROTOR PORTION, SAID OUTER ROTOR PORTION DEFINING AT LEAST ONE COLLECTION CHAMBER IN FLUID COMMUNICATION WITH SAID TRANSFER PASSAGEWAYS IN SAID INNER ROTOR PORTION FOR RECEIVING MATERIAL DISCHARAGED FROM SAID TRANSFER PASSAGEWAYS.
Claim 3
Dependent Claim
47 words
The rotor assembly of claim 1 wherein said removable outer rotor portion defines a multiplicity of collection chambers, each of said collection chambers having an opening in register with the radial extremity of a respective transfer passageway so as to receive liquids discharged from said transfer passageways.
Claim 4
Dependent Claim
23 words
The rotor assembly of claim 2 wherein each of said collection chambers is vented through the top surface of said outer rotor portion.
Claim 5
Dependent Claim
21 words
The rotor assembly of claim 1 wherein said static sample loading ports communicate with the centripetal ends of said sample-receiving chambers.
Claim 6
Dependent Claim
19 words
The rotor assembly of claim 1 wherein said transfer passageways communicate with the bottom ends of said sample-receiving chambers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-03 | 1978-08-05 | 1979-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-03 | 1982-08-05 | 1983-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-03 | 1986-08-05 | 1987-02-04 | $7700.00 | Window Closed / Lapsed |