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US3853899A
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7-alkyl-2,2-dimethyl-4-(1-aralkyl-1,2,3,4-tetrahydro-4-pyridyl)-chroman-5-ols and derivatives thereof
Assignee: Beecham Group PLC
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Filing: 1973-01-16
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Granted: 1974-12-10
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Expires: 1993-01-16
Abstract
Abstract Chromanols of the formula (II) wherein R1 is a non-aromatic hydrocarbon group of 1-20 carbon atoms, R2 is a hydrocarbon group of 1-20 carbon atoms optionally substituted by a halogen atom and X is an optionally salted, etherified or acylated hydroxyl group, and N-oxides, acidaddition and quaternary salts thereof are shown to have antihypertensive activity. Their preparation and compositions containing them are described.
Inventors
- 👤 C Fake
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; C; C07; C07G; C07G11/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
5 words
A compound of the formula
Claim 4
Dependent Claim
5 words
A compound of the formula
Claim 5
Dependent Claim
5 words
A compound of the formula
Claim 6
Dependent Claim
5 words
A compound of the formula
Claim 7
Dependent Claim
10 words
The compound according to claim 1 which is 7-(n-amyl)-4-(1-benzyl-1,2,5,6-tetrahydro-4-pyridyl)-2,2-dimethylchroman-5 -ol.
Claim 8
Dependent Claim
10 words
The compound according to claim 1 which is 7-(2-hexyl)-2,2-dimethyl-4-(1-(2-phenylethyl)-1,2,5,6-tetrahydro-4 -pyridyl)chroman-5-ol.
Claim 9
Dependent Claim
10 words
The compound according to claim 1 which is 7-(n-heptyl)-2,2-dimethyl-4-(1-benzyl-1,2,5,6-tetrahydro-4-pyridyl)-chroman -5-ol.
Claim 10
Dependent Claim
10 words
The compound according to claim 1 which is 7-(n-hexyl)-2,2-dimethyl-4-(1-(1-naphthylmethyl-1,2,5,6-tetrahydro-4 -pyridyl))-chroman-5-ol.
Claim 11
Dependent Claim
10 words
The compound according to claim 1 which is 7-(2-octyl)-2,2-dimethyl-4-(1-(2-naphthylmethyl-1,2,5,6-tetrahydro-4 -pyridyl))-chroman-5-ol.
References Cited (Backward Citations)
US3707474A
Cited
US3726883A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-09 | 1978-06-10 | 1978-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-09 | 1982-06-10 | 1982-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-09 | 1986-06-10 | 1986-12-10 | $7700.00 | Window Closed / Lapsed |