2,2-di-and 2,2,3-tri-lower alkyl chroman-and chromen-ols and salts,ethers and esters thereof

Abstract

Abstract NOVEL CHEMICAL COMPOUND ARE THEIR SALTS, ETHERS AND ESTERS ARE DISCLOSED WHEREIN THE COMPOUNDS HAVE THE FORMULAS: 2,2,3-TRI(R1-),4-(PYRIDIN-4-YL),5-X,7-R2-CHROMAN, 2,2-DI- (R1-),4-(PYRIDIN-4-YL),5-X,7-R2-2H-CHROMENE, AND 2-(O=), 4-(PYRIDIN-4-YL),5-X,7-R2-2H-CHROMENE IN WHICH R1 IS LOWER ALKYL HAVING 1 TO 6 CARBON ATOMS, R2 IS ALKYL HAVING 1 TO 20 CARBON ATOMS OR CYCLOALKYLLOWER-ALKYL, THE CYCLOALKYL PART HAVING 3 TO 8 CARBON ATOMS, AND X IS OH OR A PHARMACEUTICALLY ACCEPTABLE SALT INCLUDING AN ALKALI METAL SALT OR ALKALINE EARTH METAL SALT, OR AN ETHERIFIED OR ESTERIFIED OH-GROUP, EXCLUSIVE OF AMINO ACID ESTERS. COMPOUNDS I AND II POSSESS BENEFICIAL PHARMACODYNAMIC ACTIVITY WITH RESPECT TO THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEM, AND COMPOUNDS III ARE INTERMEDIATES FOR USE IN THE PREPARATION OF COMPOUNDS I AND II.

Inventors

• 👤 William Raymond Thompson
• 👤 Raj Kumar Razdan

Bibliographic Details