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Patent US3846353A successfully refreshed from Google Patents.
US3846353A
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Nonthrombogenic plastic material and method for making the same
Assignee: DEPARTMENT OF HEALTH EDUCATION
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Filing: 1970-06-08
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Granted: 1974-11-05
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Expires: 1990-06-08
Abstract
Abstract Novel water-insoluble, organic solvent-soluble, long chain alkyl quaternary ammonium salts of heparin, heparinized polymers made therewith, and the method of making the same are disclosed.
Inventors
- 👤 H Grotta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:15
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
71 words
A METHOD OF MAKING A NONTHROMBOGENIC PLASTIC MATERIAL COMPRISING THE STEPS OF EXPOSING A POLYMERIC PLASTIC TO AN ORGANIC SOLVENT SOLUTION OF WATER-INSOLUBLE, ORGANIC SOLVENTSOLUBLE, PLASTIC-COMPATIBLE LONG CHAIN ALKYL QUATERNARY AMMONIUM SALT AT AMBIENT TEMPERATURE SAID LONG-CHAIN ALKYL QUATERNARY AMMONIUM SALT HAVING FROM 2 TO 4 ALKYL GROUPS EACH HAVING FROM ABOUT 10 TO ABOUT 30 CARBON ATOMS, AND THEREAFTER EXPOSING SAID POLYMERI TO A SOLUTION OF HEPARIN AT AMBEINT TEMPERATURE.
Claim 2
Independent Claim
71 words
A METHOD OF MAKING A NONTHROMBOGENIC PLASTIC MATERIAL COMPRISING THE STEPS OF EXPOSING A POLYMERIC PLASTIC TO AN ORGANIC SOLVENT SOLUTION OF WATER-INSOLUBLE, ORGANIC SOLVENTSOLUBLE, PLASTIC-COMPATIBLE LONG CHAIN ALKYL QUATERNARY AMMONIUM SALT AT AMBIENT TEMPERATURE SAID LONG-CHAIN ALKYL QUATERNARY AMMONIUM SALT HAVING FROM 2 TO 4 ALKYL GROUPS EACH HAVING FROM ABOUT 10 TO ABOUT 30 CARBON ATOMS, AND THEREAFTER EXPOSING SAID POLYMERI TO A SOLUTION OF HEPARIN AT AMBEINT TEMPERATURE.
Claim 3
Dependent Claim
16 words
The method of claim 1, wherein said 2 to 4 alkyl groups have 12 carbon atoms.
Claim 4
Dependent Claim
33 words
The method of claim 2, wherein said quaternary ammonium salt is selected from the group consisting of tridodecylmethyl ammonium salts, tetradodecyl ammonium salts, 1,2-ethylene-bis-tridodecyl ammonium salts, tridodecylbenzyl ammonium salts, and 1,5-pentane-bis-tridodecyl ammonium salts.
Claim 5
Dependent Claim
39 words
The method of claim 1, wherein said plastic is a member of the group consisting of polyethylene, polypropylene, polyurethanes, polycarbonates, polytetrafluoroethylene, silicone rubber, polyesters, nylons, natural rubber, polyvinyl chloride, acrylics, polystyrene, and a copolymer of polycarbonate and silicone rubber.
Claim 6
Dependent Claim
20 words
The method of claim 1, wherein said organic solvent solution of said quaternary ammonium salt is a 10 percent solution.
Claim 7
Dependent Claim
22 words
The method of claim 5, wherein said organic solvent is selected from the group consisting of toluene, petroleum ether, and mixtures thereof.
Claim 8
Dependent Claim
23 words
The method of claim 1, wherein said plastic is exposed to said organic solvent solution for from about 3 to about 4 hours.
Claim 9
Dependent Claim
18 words
The method of claim 1, wherein said solution of heparin is a 0.25 percent solution of sodium heparinate.
Claim 10
Dependent Claim
18 words
The method of claim 8, wherein said sodium heparinate is dissolved in a mixture of methanol and water.
Claim 11
Dependent Claim
19 words
The method of claim 1 wherein said plastic is exposed to said solution of heparin for about 4 hours.
Claim 12
Dependent Claim
31 words
The method of claim 1, wherein said plastic is dried subsequent to being exposed to said solution of quaternary ammonium salt and prior to being exposed to said solution of heparin.
Claim 13
Dependent Claim
29 words
A nonthrombogenic plastic material having incorporated therein a complex of heparin and a water-insoluble, solvent-soluble, plastic-compatible long chain alkyl quaternary ammonium salt applied by the method of claim 1.
Claim 14
Dependent Claim
18 words
A plastic material according to claim 12, wherein said 2 to 4 alkyl groups have 12 carbon atoms.
Claim 15
Dependent Claim
36 words
A plastic material according to claim 13, wherein said quaternary ammonium salt is selected from the group consisting of tridodecylmethyl ammonium salts, tetradodecyl ammonium salts, 1, 2-ethylene-bis-tridodecyl ammonium salts, tridodecylbenzyl ammonium salts, and 1,5-pentane-bis-tridodecyl ammonium salts.
Claim 16
Dependent Claim
41 words
A plastic material according to claim 12, wherein said plastic is a member of the group consisting of polyethylene, polypropylene, polyurethanes, polycarbonates, polytetrafluoroethylene, silicone rubber, polyesters, nylons, natural rubber, polyvinyl chloride, acrylics, polystyrene, and a copolymer of polycarbonate and silicone rubber.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-11-04 | 1978-05-06 | 1978-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-11-04 | 1982-05-06 | 1982-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-11-04 | 1986-05-06 | 1986-11-05 | $7700.00 | Window Closed / Lapsed |