Patent US3714154A successfully refreshed from Google Patents.
US3714154A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Recovery of cephalothin salts
Assignee: Eli Lilly and Co
•
Filing: 1970-12-24
•
Granted: 1973-01-30
•
Expires: 1990-12-24
Abstract
Abstract This invention is addressed to an improved method for the recovery of alkali metal salts of caphalothin from aqueous solution in which a non-toxic alkali metal salt is added in the aqueous solution to precipitate the cephalothin salts substantially free of impurities.
Inventors
- 👤 R Pfeiffer
- 👤 K Yang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:00
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/26; C07D501/34
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
82 words
In a process for the recovery of an alkali metal salt of 7-(2''-thienylacetamido)cephalosporanic acid from an aqueous solution thereof, the improvement which comprises adding a non-toxic alkali metal salt selected from the group consisting of an alkali metal halide and an alkali metal salt of an organic carboxylic acid having a pKa less than 5 to the aqueous solution to precipitate the salt of the 7-(2''-thienylacetamido)cephalosporanic acid, and separating the precipitate of the alkali metal salt of the 7-(2''-thienylacetamido)cephalosporanIc acid thus formed.
Claim 2
Dependent Claim
82 words
In a process for the recovery of an alkali metal salt of 7-(2''-thienylacetamido)cephalosporanic acid from an aqueous solution thereof, the improvement which comprises adding a non-toxic alkali metal salt selected from the group consisting of an alkali metal halide and an alkali metal salt of an organic carboxylic acid having a pKa less than 5 to the aqueous solution to precipitate the salt of the 7-(2''-thienylacetamido)cephalosporanic acid, and separating the precipitate of the alkali metal salt of the 7-(2''-thienylacetamido)cephalosporanIc acid thus formed.
Claim 3
Dependent Claim
25 words
A process as defined in claim 1 wherein the alkali metal of the non-toxic salt corresponds to the alkali metal of the cephalosporanic acid salt.
Claim 4
Dependent Claim
23 words
A process as defined in claim 1 wherein the aqueous solution contains at least 10 percent by weight of the cephalosporanic acid salt.
Claim 5
Dependent Claim
16 words
A process as defined in claim 1 wherein the non-toxic salt is an alkali metal lactate.
Claim 6
Dependent Claim
32 words
A process as defined in claim 1 wherein the concentration of the cephalothin salt in the aqueous solution is within the range of 10 percent by weight up to the saturation concentration.
Claim 7
Dependent Claim
39 words
A process as defined in claim 1 wherein the non-toxic salt is employed in an amount within the range of 0.5 to 8.0 parts by weight per part by weight of the cephalosporanic acid salt in the aqueous solution.
Claim 8
Dependent Claim
30 words
A process as defined in claim 1 wherein the non-toxic alkali metal salt is added to the aqueous solution in the form of a concentrated solution in a liquid carrier.
Claim 9
Dependent Claim
25 words
A process as defined in claim 9 wherein the liquid carrier is selected from the group consisting of water, a lower alkanol and mixtures thereof.
Claim 10
Dependent Claim
73 words
In a process for the recovery of the sodium salt of 7-(2''-thienylacetamido)cephalosporanic acid from an aqueous solution thereof, the improvement comprising adding a non-toxic sodium salt selected from the group consisting of sodium halide and an alkali metal salt of an organic carboxylic acid having a pKa less than 5 to the aqueous solution to precipitate the cephalosporanic acid salt, and separating the precipitate of the sodium salt of 7-(2''-thienylacetamido)cephalosporanic acid thus obtained.
Claim 11
Dependent Claim
73 words
In a process for the recovery of the sodium salt of 7-(2''-thienylacetamido)cephalosporanic acid from an aqueous solution thereof, the improvement comprising adding a non-toxic sodium salt selected from the group consisting of sodium halide and an alkali metal salt of an organic carboxylic acid having a pKa less than 5 to the aqueous solution to precipitate the cephalosporanic acid salt, and separating the precipitate of the sodium salt of 7-(2''-thienylacetamido)cephalosporanic acid thus obtained.
Claim 12
Dependent Claim
15 words
A process as defined in claim 9 wherein the non-toxic sodium salt is sodium lactate.
References Cited (Backward Citations)
US3218318A
Cited
US3351597A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-01-30 | 1976-07-31 | 1977-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-01-30 | 1980-07-31 | 1981-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-01-30 | 1984-07-31 | 1985-01-30 | $7700.00 | Window Closed / Lapsed |