US3351597A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for acylating 7-amino cephalosporanic acid
Assignee: Eli Lilly and Co
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Filing: 1966-11-23
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Granted: 1967-11-07
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Expires: 1986-11-23
Abstract
No abstract record available.
Inventors
- 👤 Jr Harvey M Higgins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 14:13
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/02; C07D501/04; C07D501/06
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
113 words
IN A PROCESS FOR ACYLATING 7-ACA WITH AN ACYL HALIDE TO OBTAIN A CEPHALOSPORIN ACYLATION PRODUCT, THE IMPROVEMENT WHICH COMPRISES CONTACTING THE 7-ACA WITH THE ACYL HALIDE IN THE PRESENCE OF (1) A SUBSTANTIALLY ANHYDROUS ORGANIC LIQUID DILUENT WHICH IS A NONSOLVENT FOR THE 7-ACA, CHEMICALLY INERT TOWARD THE ACYL HALIDE, BUT WHICH IS A SOLVENT FOR THE CEPHALOSPORIN ACYLATION PRODUCT, AND (2) AT LEAST ONE MEMBER OF THE GROUP CONSISTING OF UREA, THIOUREA, BIURET, DITHIOBIURET, PHENYLUREA, 1,1-DIPHENYLUREA, AND PHENYLTHIOUREA, SAID COMPONENT (2) BEING PRESENT IN THE REACTION MIXTURE IN AN AMOUNT RANGING FROM ABOUT 0.5 TO ABOUT 2.0 MOLAR EQUIVALENTS OF SAID COMPONENT (2) FOR EACH MOLAR EQUIVALENT OF THE ACYL HALIDE.
Claim 2
Dependent Claim
113 words
IN A PROCESS FOR ACYLATING 7-ACA WITH AN ACYL HALIDE TO OBTAIN A CEPHALOSPORIN ACYLATION PRODUCT, THE IMPROVEMENT WHICH COMPRISES CONTACTING THE 7-ACA WITH THE ACYL HALIDE IN THE PRESENCE OF (1) A SUBSTANTIALLY ANHYDROUS ORGANIC LIQUID DILUENT WHICH IS A NONSOLVENT FOR THE 7-ACA, CHEMICALLY INERT TOWARD THE ACYL HALIDE, BUT WHICH IS A SOLVENT FOR THE CEPHALOSPORIN ACYLATION PRODUCT, AND (2) AT LEAST ONE MEMBER OF THE GROUP CONSISTING OF UREA, THIOUREA, BIURET, DITHIOBIURET, PHENYLUREA, 1,1-DIPHENYLUREA, AND PHENYLTHIOUREA, SAID COMPONENT (2) BEING PRESENT IN THE REACTION MIXTURE IN AN AMOUNT RANGING FROM ABOUT 0.5 TO ABOUT 2.0 MOLAR EQUIVALENTS OF SAID COMPONENT (2) FOR EACH MOLAR EQUIVALENT OF THE ACYL HALIDE.
References Cited (Backward Citations)
US3297692A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1970-11-06 | 1971-05-08 | 1971-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1974-11-06 | 1975-05-08 | 1975-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1978-11-06 | 1979-05-08 | 1979-11-07 | $7700.00 | Window Closed / Lapsed |