Patent US3133861A successfully refreshed from Google Patents.
US3133861A
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Attenuated live measles virus vaccine and method of production
Assignee: Dow Chemical Co
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Filing: 1961-11-08
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Granted: 1964-05-19
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Expires: 1981-11-08
Abstract
No abstract record available.
Inventors
- 👤 Anton J F Schwarz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:35
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/155; A61K39/165; A61K2039/51; A61K2039/525; A61K2039/5254; C; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18411; C12N2760/18434
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
172 words
A METHOD FOR PREPARING AN ATTENUATED LIVE VIRUS SUITABLE FOR IMMUNIZING HUMANS AGAINST MEASLES WHICH COMPRISES THE STEPS OF INTRODUCING A LIVE MEASLES VIRUS, WHICH HAS BEEN ADAPTED TO GROW IN AVIAN EMBRYO TISSUE CELL CULTURE BUT WHICH IS ITSELF INCAPABLE OF IMMUNIZING HUMANS WITHOUT PRODUCING A HIGH PROPORTION OF RELATIVELY SEVERE UNDESIRABLE REACTIOONS, INTO TISSUR CULTURES OF AVIAN EMBRYL TISSUES IN A NUTRIENT FLUID, CAPABLE OF SUPPORTING SAID TISSUE GROWTH AND WHICH IS NON-TOXIC TO SAID VIRUS, INVUBATING SAID TUSSIE-CONTAINING NUTRIENT FLUID AT A TEMPERATURE OF FROM ABOUT 28*C. TO ABOUT 32*C. FOR A PERIOD OF TIME TO FOSTER GROWTH OF SAID VIRUS, HARVESTING AT LEAST A PORTION OF THE VIRUS SO PRODUCED AND REINTRODUCING SUCH HARVESTED VIRUS INTO FRESH CULTURES OF AVIAN EMBRYO TISSUE, AND REPEATING SUCH CULTURE PASSAGE OF THE VIRUS SERIALLY WITH INCUBATION AT TEMPERATURES OF FROM ABOUT 28*C. TO ABOUT 32*C. FOR A SUFFICIENT NUMBER OF PASSAGES TO PRODUCE A VIRUS ATTENUATED AS REGARDS SEVERITY OF HUMAN REACTION THERETO WITHOUT LOSS OF ANTIGENICITY FOR PRODUCING MEASLES ANTIBODIES.
Claim 2
Independent Claim
172 words
A METHOD FOR PREPARING AN ATTENUATED LIVE VIRUS SUITABLE FOR IMMUNIZING HUMANS AGAINST MEASLES WHICH COMPRISES THE STEPS OF INTRODUCING A LIVE MEASLES VIRUS, WHICH HAS BEEN ADAPTED TO GROW IN AVIAN EMBRYO TISSUE CELL CULTURE BUT WHICH IS ITSELF INCAPABLE OF IMMUNIZING HUMANS WITHOUT PRODUCING A HIGH PROPORTION OF RELATIVELY SEVERE UNDESIRABLE REACTIOONS, INTO TISSUR CULTURES OF AVIAN EMBRYL TISSUES IN A NUTRIENT FLUID, CAPABLE OF SUPPORTING SAID TISSUE GROWTH AND WHICH IS NON-TOXIC TO SAID VIRUS, INVUBATING SAID TUSSIE-CONTAINING NUTRIENT FLUID AT A TEMPERATURE OF FROM ABOUT 28*C. TO ABOUT 32*C. FOR A PERIOD OF TIME TO FOSTER GROWTH OF SAID VIRUS, HARVESTING AT LEAST A PORTION OF THE VIRUS SO PRODUCED AND REINTRODUCING SUCH HARVESTED VIRUS INTO FRESH CULTURES OF AVIAN EMBRYO TISSUE, AND REPEATING SUCH CULTURE PASSAGE OF THE VIRUS SERIALLY WITH INCUBATION AT TEMPERATURES OF FROM ABOUT 28*C. TO ABOUT 32*C. FOR A SUFFICIENT NUMBER OF PASSAGES TO PRODUCE A VIRUS ATTENUATED AS REGARDS SEVERITY OF HUMAN REACTION THERETO WITHOUT LOSS OF ANTIGENICITY FOR PRODUCING MEASLES ANTIBODIES.
References Cited (Backward Citations)
US2990335A
Cited
US2912361A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1967-05-19 | 1967-11-18 | 1968-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1971-05-19 | 1971-11-18 | 1972-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1975-05-19 | 1975-11-18 | 1976-05-19 | $7700.00 | Window Closed / Lapsed |