US20040126404A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implant material
Assignee: University of Queensland
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Filing: 2003-07-29
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Granted: —
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Expires: 2023-07-29
Abstract
Abstract The present invention relates generally to tissue implant material for use in grafting procedures. More particularly, the present invention provides non-vascular tissue for use as vascular graft material. The present invention further contemplates a method of vascular grafting using non-vascular tissue. The tissue of the present invention is preferably autologous relative to the recipient of the graft and is conveniently prepared around or on a molding support or other foreign body inserted into a body cavity of the intended recipient of the graft. The tissues and methods of the present invention are particularly useful in the treatment or prophylaxis of diseased or damaged blood vessels such as in atherosclerosis.
Inventors
- 👤 Julie Campbell
- 👤 Gordon Campbell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:55
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3886; A61L27/3604; A61L27/3804; A61L27/3826; A61L27/383; A61L27/50; A61L27/507
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
23 words
1 . An isolated tissue for a vascular graft said tissue comprising granulation tissue produced on or around or in a molding support.
Claim 2
Dependent Claim
23 words
1 . An isolated tissue for a vascular graft said tissue comprising granulation tissue produced on or around or in a molding support.
Claim 3
Dependent Claim
18 words
2 . The isolated tissue of claim 1 wherein the granulation tissue is covered by non-thrombogenic mesothelial cells.
Claim 4
Dependent Claim
18 words
3 . The isolated tissue of claim 1 or 2 wherein the molding support is a tubular molding.
Claim 5
Dependent Claim
22 words
4 . The isolated tissue of claim 3 wherein the tissue is a tubular tissue section comprising living myofibroblasts within granulation tissue.
Claim 6
Dependent Claim
25 words
5 . The isolated tissue of any one of claims 1 or 2 wherein the tissue is a substitute blood vessel or a portion thereof.
Claim 7
Dependent Claim
16 words
6 . The isolated tissue of claim 5 wherein the substitute blood vessel is substitute artery.
Claim 8
Dependent Claim
39 words
7 . A method of making isolated tissue for a vascular graft placing a molding support within a body cavity for a time and under conditions sufficient for granulation tissue to form on, around or in said moulding support.
Claim 9
Dependent Claim
39 words
7 . A method of making isolated tissue for a vascular graft placing a molding support within a body cavity for a time and under conditions sufficient for granulation tissue to form on, around or in said moulding support.
Claim 10
Dependent Claim
17 words
8 . The method of claim 7 wherein the granulation tissue is covered by non-thrombogenic mesothelial cells.
Claim 11
Dependent Claim
17 words
9 . The method of claim 7 or 8 wherein the molding support is a tubular molding.
Claim 12
Dependent Claim
21 words
10 . The method of claim 9 wherein the tissue is a tubular tissue section comprising living myofibroblasts within granulation tissue.
Claim 13
Dependent Claim
24 words
11 . The method of any one of claims 7 or 8 wherein the tissue is a substitute blood vessel or a portion thereof.
Claim 14
Dependent Claim
18 words
12 . The isolated tissue of claim 11 , wherein the tissue is implanted as a substitute artery.
Claim 15
Dependent Claim
46 words
13 . A method of producing substitute tissue comprising inserting a molding support within a body cavity for a time and under conditions sufficient for granulation tissue comprising myofibroblasts to form in, or around the molding support and removing said moulding support from the body cavity.
Claim 16
Dependent Claim
46 words
13 . A method of producing substitute tissue comprising inserting a molding support within a body cavity for a time and under conditions sufficient for granulation tissue comprising myofibroblasts to form in, or around the molding support and removing said moulding support from the body cavity.
Claim 17
Dependent Claim
15 words
14 . The method of claim 13 wherein the molding support is a tubular molding.
Claim 18
Dependent Claim
16 words
15 . The method of claim 14 wherein the substitute tissue is a substitute blood vessel.
Claim 19
Dependent Claim
14 words
16 . The method of claim 15 wherein the blood vessel is an artery.
Claim 20
Dependent Claim
20 words
17 . The method of any one of claims 13 to 16 wherein the molding support is a biodegradable matrix.
Claim 21
Dependent Claim
52 words
18 . A method for producing a substitute blood vessel comprising inserting into a body cavity of a recipient a molding comprising a tube for a time and under conditions sufficient for granulation tissue to form with myofibroblasts in, on or around the molding support and removing the molding from the cavity.
Claim 22
Dependent Claim
52 words
18 . A method for producing a substitute blood vessel comprising inserting into a body cavity of a recipient a molding comprising a tube for a time and under conditions sufficient for granulation tissue to form with myofibroblasts in, on or around the molding support and removing the molding from the cavity.
Claim 23
Dependent Claim
15 words
19 . The method of claim 18 wherein the body cavity is the peritoneal cavity.
Claim 24
Dependent Claim
20 words
20 . The method of claim 18 or 19 wherein the tubular molding is silastic tubing or an equivalent tubing.
Claim 25
Dependent Claim
42 words
21 . The method of claim 20 wherein the diameter of the silastic tubing or an equivalent tubing is from about 0.1 mm to about 10 mm and the length of the tubing is from about 1 mm to about 1000 mm.
Claim 26
Dependent Claim
17 words
22 . The method of claim 18 or 19 wherein the molding support is a biodegradable matrix.
Claim 27
Dependent Claim
62 words
23 . An isolated substitute blood vessel maintained in a frozen state for use by a mammal in which it is produced said substitute blood vessel formed by placing a tubular molding within a body cavity for a time and under conditions sufficient for granulation tissue comprising myofibroblasts to form in, on or around the molding support and removing said tubular molding.
Claim 28
Dependent Claim
62 words
23 . An isolated substitute blood vessel maintained in a frozen state for use by a mammal in which it is produced said substitute blood vessel formed by placing a tubular molding within a body cavity for a time and under conditions sufficient for granulation tissue comprising myofibroblasts to form in, on or around the molding support and removing said tubular molding.
Claim 29
Dependent Claim
18 words
24 . The isolated substitute blood vessel of claim 22 wherein the body cavity is the peritoneal cavity.
Claim 30
Dependent Claim
21 words
25 . The isolated blood vessel of claim 22 or 23 wherein the mammal is a human or laboratory test animal.
Claim 31
Dependent Claim
17 words
26 . The isolated blood vessel of claim 23 wherein the molding support is a biodegradable matrix.
Claim 32
Dependent Claim
63 words
27 . A method of treating atherosclerosis or other blood vessel disease, comprising by-passing or replacing a damaged blood vessel by grafting a substitute blood vessel, said substitute tissue comprising myofibroblasts within granulation tissue produced on, in or around a molding support inserted into a body cavity of the subject being treated, removing said molding support and then grafting said tissue where required.
Claim 33
Dependent Claim
63 words
27 . A method of treating atherosclerosis or other blood vessel disease, comprising by-passing or replacing a damaged blood vessel by grafting a substitute blood vessel, said substitute tissue comprising myofibroblasts within granulation tissue produced on, in or around a molding support inserted into a body cavity of the subject being treated, removing said molding support and then grafting said tissue where required.
Claim 34
Dependent Claim
21 words
28 . The method of claim 27 , wherein granulation tissue is everted as it is removed from the mold support.
Claim 35
Dependent Claim
16 words
29 . The method of claim 28 , wherein the body cavity is the peritoneal cavity.
Claim 36
Dependent Claim
22 words
30 . The method of claim 27 , wherein the blood vessel is in a human subject or a laboratory test animal.
Claim 37
Dependent Claim
100 words
31 . A prosthetic device which facilitates the provision of a foreign body to a body cavity, said device comprising: an outer elongated tubular member having perforations or a permeable layer to permit passage of cells and fluid into and out of said tubular member; an inner elongated member removably insertable in said outer elongated member and comprising a tube around which or part of which vascular or non-vascular tissue can grow; and an external portion which is maintained on the skin surface or subcutaneously and through which the inner elongated member can be removed from said outer elongated member.
Claim 38
Dependent Claim
100 words
31 . A prosthetic device which facilitates the provision of a foreign body to a body cavity, said device comprising: an outer elongated tubular member having perforations or a permeable layer to permit passage of cells and fluid into and out of said tubular member; an inner elongated member removably insertable in said outer elongated member and comprising a tube around which or part of which vascular or non-vascular tissue can grow; and an external portion which is maintained on the skin surface or subcutaneously and through which the inner elongated member can be removed from said outer elongated member.
Claim 39
Dependent Claim
19 words
32 . The prosthetic device of claim 31 , wherein the device is a Tenckhoff Acute Peritoneal Dialysis Catheter.
Claim 40
Dependent Claim
19 words
33 . The prosthetic device of claim 31 , wherein said outer elongated tubular membrane is comprised of silicon.
Claim 41
Dependent Claim
16 words
34 . The prosthetic device of claim 31 , wherein said perforations are about 1.9558 millimeters.
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