Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
139 words
A process for preparing a compound of formula I wherein R¹ and R² combine to form C₄-C₆ polymethylene, -CH₂CH(CH₃)CH₂CH₂-, -CH₂C(CH₃)₂CH₂CH₂-, or -CH₂CH₂OCH₂CH₂-; or a pharmaceutically acceptable salt or solvate thereof, comprising a) reacting a compound of formula II with a compound of formula III wherein R¹ and R² are as defined above, in the presence of triphenylphosphine and diethyl azodicarboxylate; or b) reacting a compound of formula II with a compound of formula Z-CH₃-CH₂-Z in which Z is the same or different leaving group, and reacting the resulting compound of formula IV wherein Z is a leaving group, with pyrrolidine, piperidine, hexamethyleneimine, methylpyrrolidine, dimethylpyrrolidine, or morpholine; c) deprotecting the 6- and 4'-position hydroxy group of the reaction product of step a) or step b); and d) optionally salifying or forming a solvate of the reaction product of step c).
Claim 2
Dependent Claim
23 words
A process according to Claim 1 wherein R¹ and R² combine to form C₄ polymethylene and the salt thereof is the hydrochloride salt.
Claim 3
Dependent Claim
19 words
A process according to any one of Claims 1 to 2 wherein steps a), c), and d) are used.
Claim 4
Dependent Claim
19 words
A process according to any one of Claims 1 to 2 wherein steps b), c), and d) are used.
Claim 5
Dependent Claim
15 words
A process according to Claim 4 whrein Z of said formula IV compound is bromo.
Claim 6
Dependent Claim
21 words
A process according to any one of Claims 1 to 5 wherein the process is carried out in a single vessel.
Claim 7
Dependent Claim
140 words
A compound of formula I wherein R¹ and R² combine to form C₄-C₆ polymethylene, -CH₂CH(CH₃)CH₂CH₂-, -CH₂C(CH₃)₂CH₂CH₂-, or -CH₂CH₂OCH₂CH₂-; or a pharmaceutically acceptable salt or solvate thereof, when prepared by the process comprising a) reacting a compound of formula II with a compound of formula III wherein R¹ and R² are as defined above, in the presence of triphenylphosphine and diethyl azodicarboxylate; or b) reacting a compound of formula II with a compound of formula Z-CH₃-CH₂-Z in which Z is the same or different leaving group, and reacting the resulting compound of formula IV wherein Z is a leaving group, with pyrrolidine, piperidine, hexamethyleneimine, methylpyrrolidine, dimethylpyrrolidine, or morpholine; c) deprotecting the 6- and 4'-position hydroxy group of the reaction product of step a) or step b); and d) optionally salifying or forming a solvate of the reaction product of step c).
Claim 8
Dependent Claim
5 words
A compound of formula II
Claim 9
Dependent Claim
16 words
A compound of formula IV wherein Z is a leaving group, particularly bromo, chloro, or iodo.
Claim 10
Dependent Claim
12 words
A compound according to Claim 9 wherein said leaving group is bromo.