Patent EP0533262A1 successfully refreshed from Google Patents.
EP0533262A1
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EP
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Porous membranes based on unstable polymer solutions
Assignee: Kontron Instruments Holding NV
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Filing: 1992-09-11
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Granted: —
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Expires: 2012-09-11
Abstract
Abstract Porous, distensible, gel-like membranes which in tubular form are suitable as implants, e.g., vascular prostheses and a process for the preparation thereof is described. The membranes are formed by a spraying, phase-inversion technique which employs thermodynamically unstable polymer solutions and is accomplished by separately spraying the unstable solution and a nonsolvent onto a rotating surface. Prostheses from the highly porous tubular membranes have shown a high degree of patency and completeness of the healing process and are useful for direct implantation in the body or for extracorporeal vascular accesses.
Inventors
- 👤 Giorgio Soldani
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 16:57
CPC Classifications
C; C08; C08J; C08J9/00; C08J9/28; A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L; A61L27/00; A61L27/14; A61L27/50; A61L27/56; C08J2201/00; C08J2201/04; C08J2201/054; C08J2201/0542; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
80 words
A process for the preparation of porous polymeric membranes comprising, a) forming a solution of a polymer in a solvent for the polymer; b) adding a nonsolvent to the polymer solution until a thermodynamically unstable polymer solution is obtained; c) separately spraying the unstable polymer solution and nonsolvent from separate spray means onto a sliding and rotating mandrel means to form a precipitated material; and d) placing the precipitated material into a bath of nonsolvent to cure the precipitated material.
Claim 2
Dependent Claim
25 words
Process according to claim 1, wherein the polymer is a polyamino-acid, a polysaccharide, a cellulose derivative, an alginate, a silicone, a polyurethane or mixtures thereof.
Claim 3
Dependent Claim
14 words
Process according to claim 1, wherein the polymer is elastomeric, biocompatible and blood compatible.
Claim 4
Dependent Claim
16 words
Process according to claim 1, wherein the solvent is water-miscible and has a low boiling point.
Claim 5
Dependent Claim
21 words
Process according to claim 4, wherein the solvent is tetrahydrofuran, an amide solvent, a sulfoxide solvent, a dioxane or mixtures thereof.
Claim 6
Dependent Claim
22 words
Process according to claim 1, wherein the nonsolvent is miscible with the solvent and has a solubility parameter different from the polymer.
Claim 7
Dependent Claim
31 words
Process according to claim 1, wherein the nonsolvent is water, an alcohol, or water containing a substance which enhances the inducement of solution instability and/or precipitation of polymer from the solution.
Claim 8
Dependent Claim
16 words
Process according to claim 7, wherein the solvent is water, a lower alkanol or mixtures thereof.
Claim 9
Dependent Claim
10 words
Process according to claim 1, wherein the polymer is polyurethane.
Claim 10
Dependent Claim
12 words
Process according to claim 1, wherein the polymer is a polyether urethane-poly(dialkylsiloxane).
Claim 11
Dependent Claim
16 words
Process according to claim 10, wherein the solvent is a mixture of tetrahydrofuran and 1, 4-dioxane.
Claim 12
Dependent Claim
10 words
Process according to claim 11, wherein the nonsolvent is water.
Claim 13
Dependent Claim
158 words
Process according to claim 12, wherein the polymer solution concentration (% w/v) is from about 0.1 to 5.0, the amount of nonsolvent added to the polymer is about 1 to 50 (%v/v), the spray means is driven under gas driving pressure of from about 1 to 45 psi, the polymer solution flow rate from the spray means is about 0.5 to 5.0 ml/min, the nonsolvent flow rate from the spray means is about 0.5 to 5.0 ml/min, the angle between the separate spray means for the nonsolvent and polymer solution and the mandrel means is about 70 to 80°, the distance between nozzles of the separate spray means and the mandrel means of about 15 to 100 mm, the mandrel means diameter is from about 0.5 to 1000 mm, the speed of rotation of the mandrel means is about 100 to 2000 rpm and the sliding movement speed of the mandrel means is about 10 to 500 m/min.
Claim 14
Dependent Claim
13 words
A porous membrane prepared in accordance with the process according to claim 1.
Claim 15
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 2.
Claim 16
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 3.
Claim 17
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 4.
Claim 18
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 5.
Claim 19
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 6.
Claim 20
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 7.
Claim 21
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 8.
Claim 22
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 9.
Claim 23
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 10.
Claim 24
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 11.
Claim 25
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 12.
Claim 26
Dependent Claim
12 words
A porous membrane prepared in accordance with the process of claim 13.
References Cited (Backward Citations)
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