Method and preparation for the separation of heparin from blood in vitro

Abstract

Abstract A method and a preparation for the separation of heparin from blood or blood plasma in vitro is described. The preparation contains at least one blood-insoluble starch and/or cellulose derivative having tertiary or quaternary amino groups with a preferred exchange capacity of 0.3 to 1.3 mmol/g bound thereto. Particularly advantageous derivatives are imidazolium-N.N'-diyl-bis(2-hydroxy-3-propyl)cellulose ether chloride and imidazolium-N,N'-diyl-bis(2-hydroxy-3-propyl)ether chloride of crosslinked starch. The preparation, which is preferably present in tablet form, contains up to 12 parts by weight of microcrystalline cellulose per part by weight of the starch or cellulose derivative. The starch or cellulose derivative preferably has a particle size of 50 to 300 mu m, but it is also possible to use derivatives of smaller or larger particle size. The preparation can be used in medicine and in particular in haematology for the determination of the real haemostatic potential, and everywhere that a simple and rapid separation of heparin from blood and blood plasma is required in vitro.

Inventors

• 👤 Miroslav Dipl.-Ing. Csc Antal
• 👤 Rudolf Dipl.-Ing. Csc Toman

Bibliographic Details