EP0165568A2
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EP
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Process for the specific adsorption of heparin
Assignee: B Braun Holding AG
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Filing: 1985-06-14
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Granted: —
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Expires: 2005-06-14
Abstract
Abstract A process for the specific adsorption of heparin and other heparin-like substances which comprises flowing a buffered solution of whole blood, from which corpuscular blood constituents have been removed, plasma and/or solutions containing whole blood or plasma through an! adsorber capsule containing a medium that adsorbs heparin: and other heparin-like substances at an acid pH, preferably in the range of 4.0 to 5.5. Preferably, the process is carried out in a closed, extracorporeal circulation and the medium possesses anion exchange resin properties.
Inventors
- 👤 Dietrich Dr. Siedel
- 👤 Wolfgang Dr. Feller
- 👤 Gerhard Dr. Rosskopf
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 13:24
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; A61M1/34; A61M1/3472; A61M1/3486; A61M1/3672; A61M1/3675; Y; Y10; Y10S; Y10S435/00; Y10S435/803
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
137 words
A process for the specific adsorption of heparin and other heparin-like substances from whole blood, plasma and/or solutions containing whole blood or plasma, which comprises the steps of: a) providing a solution of whole blood, plasma and/or solutions containing whole blood or plasma containing heparin and/or other heparin-like substances; b) separating corpuscular blood constituents from the solution, if necessary; c) buffering the solution by means of a suitable buffer to an acid pH range; d) flowing the buffered solution through an adsorber capsule containing a medium that adsorbs heparin and other heparin-like substances thereby removing a substantial amount of heparin and other heparin-like substances from the buffered solution; and e) adjusting the pH of the buffered solution to the physiological conditions appropriate to a desired subject; whereby the process is carried out in a closed, extracorporeal circulation.
Claim 2
Dependent Claim
137 words
A process for the specific adsorption of heparin and other heparin-like substances from whole blood, plasma and/or solutions containing whole blood or plasma, which comprises the steps of: a) providing a solution of whole blood, plasma and/or solutions containing whole blood or plasma containing heparin and/or other heparin-like substances; b) separating corpuscular blood constituents from the solution, if necessary; c) buffering the solution by means of a suitable buffer to an acid pH range; d) flowing the buffered solution through an adsorber capsule containing a medium that adsorbs heparin and other heparin-like substances thereby removing a substantial amount of heparin and other heparin-like substances from the buffered solution; and e) adjusting the pH of the buffered solution to the physiological conditions appropriate to a desired subject; whereby the process is carried out in a closed, extracorporeal circulation.
Claim 3
Dependent Claim
36 words
The process according to claim 1 further comprising the step of: f) recombining the corpuscular blood constitutents with the solution of step (e) adjusted to the pH appropriate to the physiological conditions of a desired subject.
Claim 4
Dependent Claim
36 words
3 . The process according to claim 1 wherein the adsorber capsule comprises a sterilized, clylindrical capsule containing a cap and bottom equipped with central intake and outlet nozzzles and one or more circular double screens.
Claim 5
Dependent Claim
17 words
The process according to claim 3 wherein the screens have a mesh between 50 to 100 µm.
Claim 6
Dependent Claim
33 words
The process according to claim 1 wherein the buffered solution flows through the adsorber capsule at a rate of flow between 60 ml/hr and 25 L/hr, preferably between 1.5 L/hr and 12 L/hr.
Claim 7
Dependent Claim
24 words
6 . The process according to claim 1 wherein the buffered solution has a pH between 4.0 and 5.5, preferably between 4.7 and 5.2.
Claim 8
Dependent Claim
33 words
The process according to claim 1 wherein the related heparin substances are chosen from the group consisting of heparin fractions, heparin derivatives, heparin fragments, heparinoids, and polyanionic glycosamino glycan containing sulfate ester groups.
Claim 9
Dependent Claim
28 words
The process according to claim 1 wherein the separation of the solution from corpuscular blood constituents is achieved through the use of one or more membrane plasma filters.
Claim 10
Dependent Claim
26 words
The process according to claim 1 wherein the separation of the solution from the corpuscular blood constituents is achieved through the use of a filter cascade.
Claim 11
Dependent Claim
13 words
10,. The process according to claim 1 wherein the buffer is sodium acetate.
Claim 12
Dependent Claim
39 words
The process according to claim 1 wherein the medium of the adsorber capsule is selected from the group consisting of an ion exchange resin acting as an anion exchanger and a macroporous anion exchange resin possessing basic anchor groups.
Claim 13
Dependent Claim
17 words
The process according to claim 1 wherein the adsorber capsule is equipped with an adsorption filter cartridge.
Claim 14
Dependent Claim
51 words
The process according to claim 1 wherein the adsorber capsule contains an adsorption filter cartridge comprising a supporting screen with a solid or hollow core, around which screen is wound a fiber mat on a cellulose base that possesses anion exchange propercies thereby carable of acting as an active adsorber material.
Claim 15
Dependent Claim
27 words
14 . The process according to claim 1 wherein the adsorber capsule is filled with a gel possessing anion exchange properties and which is moistened with water.
Claim 16
Dependent Claim
38 words
The process according to claim 1 wherein the adsorber capsule has a heparin capacity between about 10,000 and 100,000 IU of heparin, and a capacity for heparinoids, heparin fractions, heparin fragments and heparin derivatives of about 2 grams.
Claim 17
Dependent Claim
44 words
The process according to claim 1 wherein the adsorber capsule is sterilized by a method selected from the group consisting of exposure to gamma rays, treatment with ethylene oxide and heat treatment prior to the flowing of the buffered solution through the adsorber capsule.
Claim 18
Independent Claim
141 words
A device for the specific adsorption of heparin and related heparin substances from whole blood, plasma and/or solutions containing whole blood or plasma comprising: a) a housing means composed of physiologically acceptable materials having a cap and bottom surfaces and a central intake nozzle and an outlet nozzle in connection therewith; b) an ion exchange medium which is situated in the interior of said adsorber capsule that is capable of adsorbing heparin and other heparin-like substances; c) a feeding line connected to said central intake nozzle; d) a draining line connected to said outlet nozzle; whereby whole blood, plasma a nd/ or solutions containing whole blood or plasma containing heparin and/or other heparin-like substances can be passed through the feeding line into the central intake nozzle, through the in exchange material, out of the outlet nozzle and through the draining line.
Claim 19
Independent Claim
141 words
A device for the specific adsorption of heparin and related heparin substances from whole blood, plasma and/or solutions containing whole blood or plasma comprising: a) a housing means composed of physiologically acceptable materials having a cap and bottom surfaces and a central intake nozzle and an outlet nozzle in connection therewith; b) an ion exchange medium which is situated in the interior of said adsorber capsule that is capable of adsorbing heparin and other heparin-like substances; c) a feeding line connected to said central intake nozzle; d) a draining line connected to said outlet nozzle; whereby whole blood, plasma a nd/ or solutions containing whole blood or plasma containing heparin and/or other heparin-like substances can be passed through the feeding line into the central intake nozzle, through the in exchange material, out of the outlet nozzle and through the draining line.
Claim 20
Dependent Claim
16 words
The device according to claim 17 wherein the housing means is a substantially cylindrical adsorber capsule.
Claim 21
Dependent Claim
31 words
1 9. The device according to claim 18 wherein the cylindrical adsorber capsule has a length of between 4 to 30 cm, and a diameter of between 2 to 10 cm.
Claim 22
Dependent Claim
26 words
20 . The housing means according to claim 17 wherein the central intake and outlet nozzles contain circular screens of between 50 and 100 µm mesh.
Claim 23
Dependent Claim
24 words
21 . The device according to claim 20 wherein the ion exchange medium is a resin with granule size between 300 and 1,000 µm.
Claim 24
Dependent Claim
52 words
The device according to claim 17 wherein the adsorber capsule contains an adsorption filler cartridge comprising a supporting screen with a hollow or solid core, around which screen is wound a fiber mat on a cellulose base that possesses anion exchange properties thereby being capable of acting as an active adsorber material.
Claim 25
Dependent Claim
50 words
The device according to claim 17 wherein the housing means is an adsorber capsule that contains a gel moistened with water capable of adsorbing heparin and other heparin-like substances selected from the group consisting of heparin fractions, heparin fragments, heparin derivatives, heparinoids and polyanionic glycosamino glycan containing sulfate ester groups.
References Cited (Backward Citations)
No citation records indexed.
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