Patent EP0240593A1 successfully refreshed from Google Patents.
EP0240593A1
Expired / Lapsed
EP
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Improved transdermal drug applicator and electrodes therefor
Assignee: Drug Delivery Systems Inc
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Filing: 1986-07-24
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Granted: —
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Expires: 2006-07-24
Abstract
Abstract An improved transdermal drug applicator (10) for application to a living body for the migration of at least one medicament through the skin (18) into the blood stream embodying at least two electrode elements forming the applicator (10) and with the electrodes separated from each other by insulating means. A reservoir means (24), in at least one of said electrode elements of said applicator (10), containing said medicament; and a circuit, including a power source (28), for supplying electric power to said electrodes and such reservoir means (24). Suitable cover means (12) partially enclosed at least said reservoir means (24), and adhesive means (36) affixes the applicator (10) to the skin (18), so as to complete an electrical circuit through the skin (18) when the applicator (10) is affixed thereto, thus creating at least one physico/chemical mass transfer phenomenon which causes said medicament to migrate through the skin (18). The reservoir means (24) contains further a plurality of high tack areas or conductive elements or micro-tubes.
Inventors
- 👤 Dan Sibalis
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 11:25
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0432; A61N1/044; A61N1/0448
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
141 words
A transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream comprising: at least two electrode elements forming said applicator separated from each other by non-conductive and impervious barrier means, reservoir means, in at least one of said electrode elements of said applicator, containing said medicament and a plurality of high tack areas, a circuit, including a power source, for supplying electric power to said electrodes and said reservoir means, cover means partially enclosing at least said reservoir means, and adhesive means for affixing said applicator to said skin, whereby an electrical circuit through the skin is formed when said applicator is affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate through the skin.
Claim 2
Dependent Claim
141 words
A transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream comprising: at least two electrode elements forming said applicator separated from each other by non-conductive and impervious barrier means, reservoir means, in at least one of said electrode elements of said applicator, containing said medicament and a plurality of high tack areas, a circuit, including a power source, for supplying electric power to said electrodes and said reservoir means, cover means partially enclosing at least said reservoir means, and adhesive means for affixing said applicator to said skin, whereby an electrical circuit through the skin is formed when said applicator is affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate through the skin.
Claim 3
Dependent Claim
18 words
A transdermal drug applicator according to claim 1, wherein said high tack areas are of elongated fiber-like construction.
Claim 4
Dependent Claim
20 words
A transdermal drug applicator according to claim 1 or 2, wherein said high tack areas are of stubby spherical shape.
Claim 5
Dependent Claim
34 words
A transdermal drug applicator according to one of the claims 1-3, wherein said reservoir means is a gel and said high tack areas are generally a harder gel than that of said reservoir means.
Claim 6
Dependent Claim
36 words
A transdermal drug applicator according to one of the claims 1-4, wherein said high tack spots comprise an adhesive gel of greater tackiness as compared to the adhesive means which affixes said applicator to said skin.
Claim 7
Dependent Claim
24 words
A transdermal drug applicator according to one of the claims 1-5, wherein said high tack areas are randomly spaced, and reinforce said drug applicator.
Claim 8
Dependent Claim
24 words
A transdermal drug applicator according to one of the claims 1-5, wherein said high tack areas are uniformly spaced, and reinforce said drug applicator.
Claim 9
Dependent Claim
26 words
A transdermal drug applicator according to one of the claims 1-7, wherein each said electrode element comprise reservoir means having a plurality of high tack spots.
Claim 10
Dependent Claim
148 words
A transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream comprising: at least two electrode elements forming said applicator separated from each other, by non-conductive and impervious barrier means, reservoir means, in at least one of said electrode elements of said applicator, containing said medicament and a plurality of conductive elements extending at least partially across said reservoir means, a circuit, including a power source, for supplying electric power to said electrodes and said reservoir means, cover means partially enclosing at least said reservoir means, and adhesive means for affixing said applicator to said skin, whereby an electrical circuit through the skin is formed when said applicator is affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate through the skin.
Claim 11
Dependent Claim
148 words
A transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream comprising: at least two electrode elements forming said applicator separated from each other, by non-conductive and impervious barrier means, reservoir means, in at least one of said electrode elements of said applicator, containing said medicament and a plurality of conductive elements extending at least partially across said reservoir means, a circuit, including a power source, for supplying electric power to said electrodes and said reservoir means, cover means partially enclosing at least said reservoir means, and adhesive means for affixing said applicator to said skin, whereby an electrical circuit through the skin is formed when said applicator is affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate through the skin.
Claim 12
Dependent Claim
48 words
A transdermal drug applicator according to claim 9, wherein said reservoir means being separated into upper and lower zones by a semi-permeable member forming a drug gradient across said reservoir means, and said plurality of conductive elements extending across at least said lower zone of said reservoir means.
Claim 13
Dependent Claim
27 words
A transdermal drug applicator according to claim 9 or 10, wherein said plurality of conductive elements extending across said upper and lower zones of said reservoir means.
Claim 14
Dependent Claim
40 words
A transdermal drug applicator according to one of the previous claims, wherein said conductive elements are fiber-like elements which are randomly spaced, and direct current flows to the zone or areas where mass transfer phenomena and drug delivery takes place.
Claim 15
Dependent Claim
40 words
A transdermal drug applicator according to one of the previous claims, wherein said conductive elements are fiber-like elements which are uniformly spaced, and direct current flows to the zone or areas where mass transfer phenomena and drug delivery takes place.
Claim 16
Dependent Claim
23 words
A transdermal drug applicator according to one of the previous claims, wherein said conductive elements comprise carbonaceous material, and reinforce said drug applicator.
Claim 17
Dependent Claim
21 words
A transdermal drug applicator according to one of the previous claims, wherein said conductive elements comprise a conductive plastic containing carbon.
Claim 18
Dependent Claim
33 words
A transdermal drug applicator according to one of the previous claims, wherein said conductive elements are tapered or conical-like in shape from widest at the upper zone and narrowest at the lower zone.
Claim 19
Dependent Claim
19 words
A transdermal drug applicator according to one of the previous claims wherein said conductive elements are elongated in shape.
Claim 20
Dependent Claim
139 words
A transdermal drug applicator for application to a living body for the migration of at least one medicament or drug through the skin into the blood stream comprising: at least two electrode elements forming said applicator separated from each other by non-conductive and impervious barrier means, drug reservoir means, in at least one of said electrode elements of said applicator, having a plurality of micro-tubes, a circuit, including a power source, for supplying electric power to said electrodes and said reservoir means, cover means partially enclosing at least said reservoir means, and adhesive means for affixing said applicator to said skin, whereby an electrical circuit through the skin is formed when said applicator is affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate through the skin.
Claim 21
Dependent Claim
139 words
A transdermal drug applicator for application to a living body for the migration of at least one medicament or drug through the skin into the blood stream comprising: at least two electrode elements forming said applicator separated from each other by non-conductive and impervious barrier means, drug reservoir means, in at least one of said electrode elements of said applicator, having a plurality of micro-tubes, a circuit, including a power source, for supplying electric power to said electrodes and said reservoir means, cover means partially enclosing at least said reservoir means, and adhesive means for affixing said applicator to said skin, whereby an electrical circuit through the skin is formed when said applicator is affixed to said skin, thereby creating at least one physico/chemical mass transfer phenomenon which causes said at least one medicament to migrate through the skin.
Claim 22
Dependent Claim
21 words
A transdermal drug applicator according to one of the previous claims wherein said electrode elements are generally of the same construction.
Claim 23
Dependent Claim
19 words
A transdermal drug applicator according to one of the claims 1-18 wherein said electrode elements are of different constructions.
Claim 24
Dependent Claim
19 words
A transdermal drug applicator according to one of the claims 1-20, wherein said electrode elements are of different size.
Claim 25
Dependent Claim
52 words
A transdermal drug applicator according to one of the claims 1-21, wherein said electrode elements comprise reservoir means and adjacent conductive elements, and said circuit being connected to said conductive elements so as to enable said at least one physico/chemical mass transfer phenomena to take place at the surface of the skin.
Claim 26
Dependent Claim
21 words
A transdermal drug applicator according to one of the claims 18-22, wherein said micro-tubes are plugged at least at one end.
Claim 27
Dependent Claim
17 words
A transdermal drug applicator according to one of the claims 18-23, wherein said micro-tubes contain said drug.
Claim 28
Dependent Claim
17 words
A transdermal drug applicator according to one of the claims 18-24, wherein said micro-tubes are randomly spaced.
Claim 29
Dependent Claim
17 words
A transdermal drug applicator according to one of the claims 18-24, wherein said micro-tubes are uniformly spaced.
Claim 30
Dependent Claim
71 words
A transdermal drug applicator according to one of the previous claims, wherein said drug applicator further including conductive elements embedded in an invert mass of material disposed atop said drug applicator with a reverse plating cell disposed therebetween, and said reverse plating cell enabling a different drug delivery sequence or a different drug delivery rates where a plurality of drugs are administered from said drug reservoir means of said electrode elements.
Claim 31
Dependent Claim
40 words
A transdermal drug applicator according to claim 27, wherein said conductive elements in said mass of invert material comprise carbonaceous material for providing an electrical current limiting effect and threshold above which current density at the skin surface cannot increase.
Claim 32
Dependent Claim
37 words
A transdermal drug applicator according to claim 27 or 28, wherein the number of said conductive elements is greater than the number of said micro-tubes, and said conductive elements and micro-tubes being disposed in any desired pattern.
Claim 33
Dependent Claim
13 words
A transdermal drug applicator according to claim 29, wherein said pattern is random.
Claim 34
Dependent Claim
19 words
A transdermal drug applicator according to one of the claims 18-30, wherein both ends of said micro-tubes are plugged.
Claim 35
Dependent Claim
20 words
A transdermal drug applicator according to claim 31, wherein said plugs employed at the ends of the micro-tubes are different.
Claim 36
Dependent Claim
20 words
A transdermal drug applicator according to one of the claims 18-32, wherein said micro-tubes are plugged by a gel-like material.
Claim 37
Dependent Claim
22 words
A transdermal drug applicator according to one of the claims 31-33 wherein said plugs are of a material which is electrically resistive.
Claim 38
Dependent Claim
18 words
A transdermal drug applicator according to one of the previous claims including a third electrode in said applicator.
Claim 39
Dependent Claim
24 words
A transdermal drug applicator according to one of the previous claims wherein at least one of said electrodes constitutes an inactive or indifferent electrode.
Claim 40
Dependent Claim
19 words
A transdermal drug applicator according to one of the previous claims, wherein all of said electodes are active electrodes.
Claim 41
Dependent Claim
26 words
A transdermal drug applicator according to one of the previous claims, wherein both ionic an non-ionic drugs are transdermally delivered by means of said active electrodes.
Claim 42
Dependent Claim
17 words
A transdermal drug applicator according to one of the previous claims, wherein said electrodes contain different drugs.
References Cited (Backward Citations)
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