EP0178601A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Transdermal drug applicator
Assignee: Drug Delivery Systems Inc
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Filing: 1985-10-11
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Granted: —
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Expires: 2005-10-11
Abstract
Abstract Transdermal drug applicator comprises reservoirs (R) contg. the drug (I), battery (B) for supplying a charge for (I), its side facing the (R), a cover (C) of electrically conductive material partially enclosing the (B) and (R) but leaving the side of (R) opposite that of (B) exposed to contact the skin and an electrical connection between (C) and (B). The cover has a lip which contacts skin when mounted on it thus fully enclosing (R) and (B) and an electrically conductive adhesive material coating on the underside of the lip. When the applicator is adhered to and mounted on the skin, a complete electrical circuit through the skin is formed and (I) migrates out of (R) and through the skin into the blood stream due to electrophoresis or electro-osmosis. An applicator for electrophoresis admin. of (I) in ionic soln. or suspension through the skin as described above is also claimed.
Inventors
- 👤 Dan Sibalis
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 04:38
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61M; A61M37/00; A61N1/0432; A61N1/044; A61N1/0448
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
241 words
A transdermal drug applicator for application to a body for migration of medicament through the skin into the blood stream of a patient comprising: a plurality of reservoir means for containing said medicament, battery means for supplying a charge for the medicament in said applicator and being adjacent one side of said reservoir means with the side of said battery means facing said reservoir means for charging the medicament, means for covering comprising an electrically conductive material for partially enclosing said battery means and said reservoir means leaving the side of said reservoir means opposite that of said battery means exposed for contacting said skin, means for electrically connecting the battery means to the cover means, said cover means having lip means for making contact with said skin when mounted on said skin leaving said battery means and reservoir means substantially fully enclosed, and an electrically conductive adhesive material coating disposed on the underside of said lip means, whereby said reservoir means renders said applicator generally conformable to the body contour of said patient, and whereby when said applicator is adhered to and mounted on said skin a complete electrical circuit through said skin is formed and the medicament in said reservoir means migrates out of said reservoir means and through said skin into the blood stream of said patient, due to the mass transfer activity attributed to at least one phenomena selected from the group consisting of electrophoresis and electro-osmosis.
Claim 2
Dependent Claim
241 words
A transdermal drug applicator for application to a body for migration of medicament through the skin into the blood stream of a patient comprising: a plurality of reservoir means for containing said medicament, battery means for supplying a charge for the medicament in said applicator and being adjacent one side of said reservoir means with the side of said battery means facing said reservoir means for charging the medicament, means for covering comprising an electrically conductive material for partially enclosing said battery means and said reservoir means leaving the side of said reservoir means opposite that of said battery means exposed for contacting said skin, means for electrically connecting the battery means to the cover means, said cover means having lip means for making contact with said skin when mounted on said skin leaving said battery means and reservoir means substantially fully enclosed, and an electrically conductive adhesive material coating disposed on the underside of said lip means, whereby said reservoir means renders said applicator generally conformable to the body contour of said patient, and whereby when said applicator is adhered to and mounted on said skin a complete electrical circuit through said skin is formed and the medicament in said reservoir means migrates out of said reservoir means and through said skin into the blood stream of said patient, due to the mass transfer activity attributed to at least one phenomena selected from the group consisting of electrophoresis and electro-osmosis.
Claim 3
Dependent Claim
26 words
The transdermal drug applicator of claim 1, in which said reservoir means is made from a microporous material whereby said medicament provides an electrical path therethrough.
Claim 4
Dependent Claim
24 words
The transdermal drug applicator of claim 2, said circuit having means to maintain constant current flow during the period said medicament is being delivered.
Claim 5
Dependent Claim
26 words
The transdermal drug applicator of claim 3, wherein said circuit having means to terminate deposition of said medicament after a predetermined quantity of medicament is delivered.
Claim 6
Dependent Claim
62 words
The transdermal drug applicator of claim 1, wherein said plurality of reservoir means are separate cell-like reservoirs for said medicament, and each said reservoir cell embodies the same structural layered elements so as to individually charge said medicament by said battery means for causing the migration of said medicament in said reservoir cells through said skin and into the patient's blood stream.
Claim 7
Dependent Claim
42 words
The transdermal drug applicator of claim 5, wherein said applicator is divided into a plurality of sections, each with battery means, and said sections being connected together at least at one point, whereby said applicator may be conformable to said body contours.
Claim 8
Dependent Claim
19 words
The transdermal drug applicator of claim 6, including parallel electrical circuit paths for the electrical circuit of said applicator.
Claim 9
Dependent Claim
41 words
The transdermal drug applicator of claim 1, including an extra electrode in a feedback loop with said electrical circuit for sensing a predetermined chemical in said body and providing a control signal for regulating the drug dosage at a desired level.
Claim 10
Dependent Claim
24 words
The transdermal drug applicator of claim 8, wherein said extra electrode is enclosed by said cover means and is disposed at said lip means.
Claim 11
Dependent Claim
40 words
The transdermal drug applicator of claim 9, wherein said extra electrode comprising a probe having a predetermined ion specific electrode or enzyme coating on the surface of said electrode portion which is in contact with the skin of said patient.
Claim 12
Dependent Claim
35 words
The transdermal drug applicator of claim 10, wherein said extra electrode is disposed in said lip I means at a sufficient distance so as not to electrically interfere with the electrical circuitry of said applicator.
Claim 13
Dependent Claim
29 words
The transdermal drug applicator of claim 11, wherein said distance is such that said lip means extends outwardly and protrudes beyond the basic shape and configuration of said applicator.
Claim 14
Dependent Claim
18 words
The transdermal drug applicator of claim 6, wherein said sections are generally all equal in size and shape.
Claim 15
Dependent Claim
18 words
The transdermal drug'applicator of claim 13, wherein each said section is provided with at least one reservoir cell.
Claim 16
Dependent Claim
29 words
The transdermal drug applicator of claim 14, wherein a plurality of reservoir cells form each said section and the number of reservoir cells of said sections are the same.
Claim 17
Dependent Claim
17 words
The transdermal drug applicator of claim 15, wherein the shape of each reservoir cell is the same.
Claim 18
Dependent Claim
19 words
The transdermal drug applicator of claim 15, wherein the shapes of said reservoir cells are not all the same.
Claim 19
Dependent Claim
30 words
The transdermal drug applicator of claim 1, wherein the pH of said medicament is maintained at a predetermined optimal value during the migration of said drug transdermally through the skin.
Claim 20
Dependent Claim
22 words
The transdermal drug applicator of claim 18, wherein the optimization of the pH value is maintained by one or more buffering agents.
Claim 21
Dependent Claim
15 words
The transdermal drug applicator of claim 1, including one or more buffers in said medicament.
Claim 22
Dependent Claim
32 words
The transdermal drug applicator of claim 20, wherein said one or more buffers is put into the range of buffer activity by pH changes which are current induced in said reservoir means.
Claim 23
Dependent Claim
45 words
The transdermal drug applicator of claim 21, wherein the electrical activity of said applicator is such that it chemically exhausts all effect of said one or more buffers, thereby rendering said one or more buffers inactive and thus dimishing the efficiency of the drug migration.
Claim 24
Dependent Claim
70 words
The transdermal drug applicator of claim 21, wherein the pH of said medicament prior to application of said applicator to one's skin is predetermined at a value which maximizes the shelf life of said drug contained in said applicator, and whereby upon application of said applicator to one's skin the current induced pH change brings the pH within the range of said one or more buffers, thus optimizing drug mobility.
Claim 25
Dependent Claim
16 words
The transdermal drug applicator of claim 1, wherein said applicator transdermally delivers a plurality of drugs.
Claim 26
Dependent Claim
47 words
The transdermal drug applicator of claim 24, wherein said plurality of reservoir means contain different medicaments, and the delivery of each of said medicaments, is independently controlled by at least one means selected from the group consisting of a current regulating means and a chemical regulating means.
Claim 27
Dependent Claim
21 words
The transdermal drug applicator of claim 25, wherein said controlling means is a solid state device pre-programmed for current and time.
Claim 28
Dependent Claim
18 words
The transdermal drug applicator of claim 25, wherein said different medicaments are released transdermally in a predetermined sequence.
Claim 29
Dependent Claim
20 words
The transdermal drug applicator of claim l, wherein the migration of medicament is substantially attributed to the pehnomena of electrophoresis.
Claim 30
Dependent Claim
20 words
The transdermal drug applicator of claim 1, wherein the migration of medicament is substantially attributed to the phenomena of electro-osmosis.
Claim 31
Dependent Claim
22 words
The transdermal drug applicator of claim 1, wherein the migration of medicament is attributed to the phenomena of both electrophoresis and electro-osmosis.
Claim 32
Dependent Claim
164 words
An applicator for the electrophoretic administration of a medicament in ionic solution or suspension through the skin into the blood stream of a patient comprising, reservoir means containing said medicament, battery means adjacent one side of said reservoir means and being electrically connected therewith, cover means of electrically conductive material at least partially enclosing said battery means and said reservoir means, said cover means having an extended portion for making contact with said skin when mounted on said skin, and electrically conductive adhesive material coating the underside of said lip, whereby when said device is mounted on said skin a complete electrical circuit through said skin is formed, and indicator means being electrically connected in said circuit, and wherein with completion of circuit the ions of said medicament in said reservoir means migrate out of said reservoir means and through said skin into the blood stream of said patient, and the indicator means is activated to indicate delivery of the medicament to the patient.
Claim 33
Dependent Claim
164 words
An applicator for the electrophoretic administration of a medicament in ionic solution or suspension through the skin into the blood stream of a patient comprising, reservoir means containing said medicament, battery means adjacent one side of said reservoir means and being electrically connected therewith, cover means of electrically conductive material at least partially enclosing said battery means and said reservoir means, said cover means having an extended portion for making contact with said skin when mounted on said skin, and electrically conductive adhesive material coating the underside of said lip, whereby when said device is mounted on said skin a complete electrical circuit through said skin is formed, and indicator means being electrically connected in said circuit, and wherein with completion of circuit the ions of said medicament in said reservoir means migrate out of said reservoir means and through said skin into the blood stream of said patient, and the indicator means is activated to indicate delivery of the medicament to the patient.
Claim 34
Dependent Claim
45 words
The applicator of claim 31, further comprising means to maintain a specific constant current flow, and wherein the medicament migrates at a specific rate of said current flow, whereby the patient is provided with an indication that the medicament is being administered at said rate.
Claim 35
Dependent Claim
23 words
The applicator of claim 32, said indicator being one selected from a light-emitting device, an appearance change device and a color change device.
Claim 36
Dependent Claim
11 words
The applicator of claim 32, wherein the indicator is an LCD.
Claim 37
Dependent Claim
39 words
The applicator of claim 32, wherein the indicator comprising electrically conductive polymeric layers forming reservoir means, and an electrochromic material disposed in said reservoir, whereby with the said current flow, the material undergoes a change visible to the patient.
Claim 38
Dependent Claim
12 words
The applicator of claim 35, said change being a color specific change..
Claim 39
Dependent Claim
21 words
The applicator of claim 35, further comprising non-conductive spacer means in said reservoir to prevent contact of said conductive polymeric layers.
Claim 40
Dependent Claim
26 words
The applicator of claim 35, wherein at least one polymeric layer has a transparent portion so that the electrochromic material change is visible to the patient.
References Cited (Backward Citations)
No citation records indexed.
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