Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
277 words
A compound having the following general formula (I) : and pharmaceutically acceptable salts thereof, wherein: R¹ and Q are each, independently, H, an alkyl having from one to twelve carbon atoms, an alkoxy having from one to twelve carbon atoms, mercapto, an alkylthio having from one to four carbon atoms, an alkylsulphinyl having from one to four carbon atoms, an alkylsulphonyl having from one to four carbon atoms, a hydroxy group, a nitro group, an amino group, a substituted amino group or a halogen, R¹ being further chosen from a methylenedioxy radical attached to adjacent carbon atoms of the benzene ring; R² is H, an alkyl having from one to twelve carbon atoms, a phenyl radical, a substituted phenyl radical or a benzyl radical; R³ is H, an alkyl having from one to twelve carbon atoms, an alkoxy having from one to twelve carbon atoms, mercapto, an alkylthio having from one to four carbon atoms, a phenylthio radical, a substituted phenylthio radical, an alkylsulphinyl having from one to four carbon atoms, a phenylsulphinyl radical, a substituted phenylsulphinyl radical, an alkylsulphonyl having from one to four carbon atoms, a phenylsulphonyl radical, a substituted phenylsulphonyl radical, an amino group, or a substituted amino group; and R⁴ is or [wherein substituted phenyl is a phenyl having one or two substituents selected from alkyl of from one to four carbons inclusive, alkoxy of from one to four carbons inclusive, hydroxy, nitro, amino, mono- or di-alkyl amino wherein alkyl is from one to four carbons, mercapto, alkylthio of from one to four carbons, methylenedioxy, or halogen and substituted amino is mono- or di-alkyl amino wherein alkyl is from one to four carbons.]
Claim 2
Dependent Claim
9 words
A compound according to Claim 1, wherein R⁴ is
Claim 3
Dependent Claim
9 words
A compound according to Claim 1, wherein R⁴ is
Claim 4
Dependent Claim
10 words
A compound according to Claim 2, wherein R³ is alkoxy.
Claim 5
Dependent Claim
119 words
A compound according to Claim 4, having one of the following names: 3-methoxy-1-methyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 1-hexyl-3-methoxy- N -1 H- tetrazol-5-yl-1 H -indole-2-carboxamide; 3-methoxy-1-nonyl- N -1 H -tetrazol-5-yl-1H-indole-carboxamide; 3-methoxy-1-(phenylmethyl)- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 3-methoxy-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 3-(1-methylethoxy)-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 1-(4-methoxyphenyl)-3-(1-methylethoxy)-N-1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-chloro-3-(1-methylethoxy)-1phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-methoxy-1-methyl-3(1-methylethoxy)- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 3,5-dimethoxy-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 3-ethoxy-5-methoxy-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-methoxy-3-(1-methylethoxy)-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 3-methoxy- N -1 H -tetrazol-5-yl-1H-indole-2-carboxamide; 3-methoxy-1-nonyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-methoxy-3-(n-nonyloxy)-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; and 3-(n-dodecyloxy)-5-methoxy-1-phenyl- N -1 H -tetrazol-5-yl--1 H -indole-2-carboxamide.
Claim 6
Dependent Claim
49 words
A compound according to Claim 2 having one of the following names: 3-(diethylamino)-5-methoxy-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-methoxy-3-(methylthio)-1-phenyl- N -1 H -tetrazol-5-yl-1- H -indole-2-carboxamide; 5-methoxy-3-[(1-methylethyl)thio]-1phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-methoxy-1-phenyl-3(phenylthio)- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; 5-methoxy-3-(methylsulphonyl)-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide; and 5-methoxy-3-[(1-methylethyl)thio]-1-phenylmethyl-N-1H-tetrazol-5-yl-1H-indole-2-carboxamide
Claim 7
Dependent Claim
24 words
A pharmaceutical composition comprising an effective amount of a compound according to any preceding claim in admixture with a pharmaceutically acceptable carrier or diluent.
Claim 8
Dependent Claim
31 words
For use in a method of treating allergies in mammals, a compound as claimed in any one of Claims 1 to 6 or a pharmaceutical composition as claimed in Claim 7.
Claim 9
Dependent Claim
53 words
A process for the preparation of a compound of formula I as defined in Claim wherein R⁴ is A, which comprises reacting a compound of the Formula (III) wherein R¹, Q, R², and R³ are as defined in Claim 1 with a compound of Formula (II) in the presence of a coupling agent.
Claim 10
Dependent Claim
49 words
A process for the preparation of a compound of formula I as defined in Claim 1 wherein R⁴ is B which comprises treating a compound of Formula (IV) wherein R¹, Q, R², and R³ are as defined in Claim 1 above by a known method or a variant thereof.
Claim 11
Dependent Claim
13 words
5-Methoxy-3-(1-methylethoxy)-1-phenyl- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide, or its L-arginate or sodium salt.
Claim 12
Dependent Claim
7 words
5-Methoxy-1-phenyl-3-(phenylmethoxy)- N -1 H -tetrazol-5-yl-1-1 H -indole-2-carboxamide.
Claim 13
Dependent Claim
7 words
1-Phenyl-3(phenylmethoxy)- N -1 H -tetrazol-5-yl-1 H -indole-2-carboxamide.