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EP0180708A1 Expired / Lapsed EP ⏱️ 0.0 years remaining

Osmotic drug delivery device

Assignee: Merck and Co Inc
•
Filing: 1983-03-08
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Granted: —
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Expires: 2003-03-08
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Abstract

Abstract An osmotic drug (or other beneficial substance) delivery device comprises a compartment with a chamber formed by an external shell (2) of a microporous material, and an overlayer of a semipermeable membrane (1) substantially covering the outer shell (2) of the chamber. Osmotic agents, adjuvants enzymes, drugs, pro-drugs, pesticides and the like are incorporated in the chamber covered by the semipermeable membrane, and external fluids that diffuse into this chamber form solutions and by osmotic pressure are forced through the exposed microporous shell (2) to the exterior of the device at a rate controlled by the permeability of the semipermeable overlay and the osmotic pressure gradient across the shell.

Inventors

  • 👤 Takeru Higuchi
  • 👤 Kenneth J. Himmelstein

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-31 12:53
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 87 words
An osmotic delivery device shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other benificial substance comprising a compartment consisting of a chamber adapted to house osmotically active agents, adsorption adjuvants, drugs, and prodrugs, the chamber being formed by an external shell (2) and, the external shell (2) being of a rigid microporous material; an overlayer of a semipermeable membrane (1), the overlayer substantially covering the external shell (2) of the chamber leaving exposed a microporous drug-emitting surface.
Claim 2
Dependent Claim 87 words
An osmotic delivery device shaped and sized for oral ingestion, implantation, rectal, vaginal or ocular insertion, for delivery of a drug or other benificial substance comprising a compartment consisting of a chamber adapted to house osmotically active agents, adsorption adjuvants, drugs, and prodrugs, the chamber being formed by an external shell (2) and, the external shell (2) being of a rigid microporous material; an overlayer of a semipermeable membrane (1), the overlayer substantially covering the external shell (2) of the chamber leaving exposed a microporous drug-emitting surface.
Claim 3
Dependent Claim 22 words
The osmotic delivery device of claim 1, wherein a quick release loading dose is external to and covers the microporous drug-emitting surface.
Claim 4
Dependent Claim 27 words
The osmotic delivery device of claim 1 or 2, wherein a cap (3) covers the drug-emitting surface designed for spontaneous removal following establishment of desired flow characteristics.
Claim 5
Dependent Claim 35 words
The osmotic delivery device of any one of claims 1 to 3 wherein the microporous material of the external shell (2) and the semipermeable membrane (1) of the overlayer are fabricated from a cellulose acetate.

References Cited (Backward Citations)

FR2386316A1 Cited
US4210139A Cited
EP0040457A2 Cited

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