Patent EP0155978A1 successfully refreshed from Google Patents.
EP0155978A1
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Method of operating a nuclear magnetic resonance spectrometer
Assignee: Max Robin Bendall Te Alligator Creek En David T P
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Filing: 1984-03-29
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Granted: —
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Expires: 2004-03-29
Abstract
Abstract In a method of operating a nuclear magnetic resonance spectrometer in relation to a sample comprising two types of heteronuclei, in which a sequence of radiofrequency pulses and delay periods, the pulses thereof having two different radiofrequencies corresponding to the two types of heteronuclei, is applied to the two nuclei such that the heteronuclear scalar coupling interactions between the two types of nuclei are allowed to evolve, the pulses of different radiofrequencies are applied to two different coils ('H coil, "C coil), respectively, each of which provides an inhomogeneous radiofrequency field, the two coils generating separate but overlapping sensitive volumes for each heteronuclear species, so that a significant signal intensity will only be obtained from sample regions where the two sensitive volumes overlap.
Inventors
- 👤 M. Robin Bendall
- 👤 David T. Pegg
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 09:29
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/28; G01R33/32; G01R33/34; G01R33/341; G01R33/44; G01R33/46; G01R33/465; G01R33/48; G01R33/483; G01R33/4831
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
122 words
A method of operating a nuclear magnetic resonance spectrometer in relation to a sample comprising two types of heteronuclei, in which a sequence of radio- frequency pulses and delay periods, the pulses thereof having two different radiofrequencies corresponding to the two types of heteronuclei, is applied to the two nuclei such that the heteronuclear scalar coupling interactions between the two types of nuclei are allowed to evolve, characterized in that the pulses of different radiofrequencies are applied to two different coils, respectively, each of which provides an inhomogeneous radio-frequency field, the two coils generating separate but overlapping sensitive volumes for each heteronuclear species, so that a significant signal intensity will only be obtained from sample regions where the two sensitive volumes overlap.
Claim 2
Independent Claim
122 words
A method of operating a nuclear magnetic resonance spectrometer in relation to a sample comprising two types of heteronuclei, in which a sequence of radio- frequency pulses and delay periods, the pulses thereof having two different radiofrequencies corresponding to the two types of heteronuclei, is applied to the two nuclei such that the heteronuclear scalar coupling interactions between the two types of nuclei are allowed to evolve, characterized in that the pulses of different radiofrequencies are applied to two different coils, respectively, each of which provides an inhomogeneous radio-frequency field, the two coils generating separate but overlapping sensitive volumes for each heteronuclear species, so that a significant signal intensity will only be obtained from sample regions where the two sensitive volumes overlap.
Claim 3
Dependent Claim
51 words
A method as claimed in claim 1 wherein the radio- frequency pulse sequence used is a DEPT or inverse DEPT sequence, said pulse sequence being modified by inclusion of phase-cycled radiofrequency pulses, in the manner of depth pulse schemes, for both types of nuclei to generate the two overlapping sensitive volumes.
Claim 4
Dependent Claim
113 words
A method as claimed in claim 1 wherein the radio- frequency pulse sequence comprises a spin-echo sequence applied to one type of nucleus, said spin-echo sequence being modified by inclusion of phase-cycled radiofrequency pulses, in the manner of a depth pulse scheme, to generate a sensitie volume for the first type of nucleus, and a radiofrequency pulse, or composite radiofrequency pulse, being applied at the middle of the spin-echo delay period to the second type of nucleus such that a sensitive volume is generated for the second type of nucleus, the said radio- frequency pulse, or composite radiofrequency pulse being modified in alternate experiments, the signals resulting from said alternate experiments being subtracted.
Claim 5
Dependent Claim
91 words
A method as claimed in claim 1 wherein the radio- frequency pulse sequence is a selective polarization transfer sequence wherein the sensitive volume for the first type of nucleus is generated by applying two different selective radiofrequency pulses, or selective composite radiofrequency pulses, to two lines of the heteronuclear scalar coupled multiplet of the first type of nucleus, and wherein the sensitive volume for the second type of nucleus is generated by inclusion of phase-cycled radiofrequency pulses, in the manner of a depth pulse scheme, for the second type of nucleus.
References Cited (Backward Citations)
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