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EP0107119A1 Expired / Lapsed EP ⏱️ 0.0 years remaining

Blood-treating material

Assignee: Toray Industries Inc
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Filing: 1983-10-04
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Granted: —
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Expires: 2003-10-04
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Abstract

Abstract The present invention provides (1) a blood-treating material comprising a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group or a carboxyl group and (2) a process for producing the blood-treating material characterized by reacting a condensing agent with a mixture of the lipopolysaccharide and the insoluble carrier. Lipopolysaccharides have been known to have antitumor effects against malignant tumors. However, they could not be used safely, since their fatal doses are very close to the minimum effective doses in the treatment of the tumors. The present invention makes it possible to reduce the lethal toxicity of the above-mentioned lipopolysaccharides and provide a new blood-treating material that can be used safely for therapy of cancer, because this blood-treating material has antitumor effects similar to those of the lipopolysaccharides derived from cell walls of Gram-negative bacteria but no fatal effects.

Inventors

  • 👤 Masashi Kodama
  • 👤 Yutaka Katayama
  • 👤 Toru Tani
  • 👤 Kazuo Teramoto
  • 👤 Matsuo Murakami

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-09 18:12
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/66; A61K35/74; A61K31/00; A61K31/70; A61K31/715; G; G01; G01N; G01N2400/00; G01N2400/10; G01N2400/50

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 27 words
A blood-treating material comprising a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group or a carboxyl group.
Claim 2
Dependent Claim 27 words
A blood-treating material comprising a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group or a carboxyl group.
Claim 3
Dependent Claim 29 words
The blood-treating material according to claim 1, wherein the content of the amino group or the carboxyl group is from about 0.1 to 5.0 meq/g of the insoluble carrier.
Claim 4
Dependent Claim 19 words
The blood-treating material according to claim 1, wherein the insoluble carrier contains an amino group and a carboxyl group.
Claim 5
Dependent Claim 33 words
The blood-treating material according to claim 1 wherein the insoluble carrier is comprised of aromatic polymeric material containing an aliphatic amino group or a carboxyl group as the substituent on the aromatic nucleus.
Claim 6
Dependent Claim 20 words
The blood-treating material according to claim 1 wherein said material is in the form of a fiber or a film.
Claim 7
Dependent Claim 22 words
A blood-treating material according to claim 5, wherein said fiber is in the form of non-woven fabric,paper, woven fabric or knitted fabric.
Claim 8
Dependent Claim 37 words
The blood-treating material according to claim 1, wherein the amount of the immobilized lipopolysaccharide derived from cell walls of Gram-negative bacteria is at least 1 mg per square meter of the surface area of the blood-treating material.
Claim 9
Dependent Claim 43 words
A process for preparing a blood-treating material characterized by reacting a condensing agent with a mixture of lipopolysaccharide and an insoluble carrier having at least one group selected from the group consisting of a primary or secondary amino group or a carboxyl group.
Claim 10
Dependent Claim 43 words
A process for preparing a blood-treating material characterized by reacting a condensing agent with a mixture of lipopolysaccharide and an insoluble carrier having at least one group selected from the group consisting of a primary or secondary amino group or a carboxyl group.
Claim 11
Dependent Claim 32 words
The process according to claim 8, wherein said condensing agent is at least one compound selected from the group consisting of 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimid, 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide, 1-cyclohexyl-3-(2-morpholino-ethyl)-carbodiimide metho-p-toluenesulfonate N,N'-dicyclohexyl-carbodiimide and Woodward Reagent K.
Claim 12
Dependent Claim 30 words
The process according to claim 8, wherein said insoluble carrier having carboxyl group is activated by at least one compound selected from the group consisting of N-hydroxysuccinimide, N-hydroxy-5-norbornene-2.3-dicarboximide and 1-hydroxybenzotriazole.

References Cited (Backward Citations)

US4003792A Cited

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